细胞表面趋化因子受体3抗体/G蛋白偶联受体
产品类别
兔抗人、大、小鼠细胞表面趋化因子受体3抗体
细胞表面趋化因子受体3抗体/G蛋白偶联受体
产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
细胞表面趋化因子受体3抗体/G蛋白偶联受体
产品介绍
G蛋白偶联受体CKR-L2( G protein-coupled receptor-2 )又称:又称G蛋白偶联受体9(GPR9)-是受体中最大的家族,大多数的细胞膜表面受体都是G蛋白偶联受体家族的成员。
G蛋白偶联受体是药物研发中最广泛应用的成功药靶,作用于G蛋白偶联受体的药物对疼痛、认知障碍、高血压、胃溃疡、鼻炎和哮喘等各类疾病具有良好的治疗作用。G-蛋白受体在目前临床上使用的约500种药物中,有30%以上以调节G蛋白偶联受体功能为靶标。
CXC-R3
CXCR-3
Interferon-inducible protein 10 receptor
IP-10 receptor
CKR-L2
CD183 antigen
G protein-coupled receptor 9
C-X-C Chemokine receptor
Summary: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10(interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization(phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
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xy-10448R phospho-HSP70 (Tyr611)磷酸化热休克蛋白-70抗体
xy-10451R phospho-HSP70 (Tyr41)磷酸化热休克蛋白-70抗体
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xy-10484R Heparanase乙酰肝素酶抗体
细胞表面趋化因子受体3抗体/G蛋白偶联受体
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xy-2075R Heme Oxygenase 1血红素氧合酶 1/热休克蛋白32抗体
xy-3491R Phospho-HER3 (Tyr1289)磷酸化HER3受体抗体
xy-3073R Phospho-HDAC4 (Ser246) + HDAC5 (Ser259) + HDAC7 (Ser155)磷酸化组蛋白去乙酰化酶4/5/7抗体
xy-1421R HP1 gamma异染色质蛋白1-γ抗体
xy-1413R Histone H1t组蛋白H1抗体
xy-1414R HDAC1组蛋白去乙酰化酶1抗体
xy-15414R HAUS3HAUS3蛋白抗体
xy-4517R Hsp93热休克蛋白93抗体
xy-3174R Phospho-HDAC3 (Ser424)磷酸化组蛋白去乙酰化酶3抗体
xy-3652R Histone H2B组蛋白H2B抗体
xy-3653R SCHAD短链L-3羟烷基辅酶A脱氢酶抗体
xy-2892R HDAC9组蛋白去乙酰化酶9抗体
xy-2893R HDAC10组蛋白去乙酰化酶10抗体
xy-3650R HOXB4HOXB4抗体
xy-3214R Phospho-HER2(Tyr1248)磷酸化HER2受体抗体
xy-2811R HDAC6组蛋白去乙酰化酶6抗体
xy-3215R phospho-HDAC6 (Ser22)磷酸化组蛋白去乙酰化酶6抗体
xy-2890R HDAC7组蛋白去乙酰化酶7抗体
xy-3216R phospho-HDAC7 (Ser358)磷酸化组蛋白去乙酰化酶7抗体
xy-2891R HDAC8组蛋白去乙酰化酶8抗体
xy-3184R Phospho-HER4 (Tyr984)磷酸化HER4抗体
xy-6458R HARS组氨酸tRNA连接酶抗体
xy-4529R NDV HN protein鸡新城疫血凝素-神经氨酸酶抗体
xy-1387R HSP105热休克蛋白105抗体
xy-1405R HNF1肝细胞核因子1α抗体