自分泌运动因子抗体

英文名称    Anei-ENPP2    

中文名称    自分泌运动因子抗体    

别    名    Autotaxin; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; ATX; ATX X; ATX-X; Autotaxin; E NPP 2; ENPP2; Ectonucleotide pyrophosphatase/phosphodiesterase 2; Extracellular lysophospholipase D; FLJ26803; LysoPLD; NPP2; PD IALPHA; PD-IALPHA; PDNP2; Phosphodiesterase I alpha; Phosphodiesterase I/nucleotide pyrophosphatase 2; Plasma lysophospholipase D; ENPP2_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  神经生物学  信号转导  细胞凋亡  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 自分泌运动因子抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    95kDa    

细胞定位    分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human ENPP2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

自分泌运动因子抗体产品介绍    background:

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] 

Function:
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

Subcellular Location:
Secreted. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.

Tissue Specificity:
Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues. 

Post-translational modifications:
N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity (By similarity). 
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. 

Similarity:
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. 
Contains 2 SMB (somatomedin-B) domains.     

自分泌运动因子抗体

hz-1293R GABBR2/GB2  G氨基丁酸B型受体2抗体

hz-5356R phospho-GABBR2 (Ser783)  磷酸化G氨基丁酸B型受体2抗体

hz-5357R phospho-GABBR2 (Ser892)   磷酸化G氨基丁酸B型受体2抗体

hz-4112R GABRG2/GABA A Receptor gamma 2  γ氨基丁酸γ2受体抗体

hz-5377R phospho-GABRG2(Ser327)  磷酸化γ氨基丁酸γ2受体抗体

hz-0325R GAD65  谷氨酸脱羧酶-65抗体

hz-5956R RHCE  Rh血型C抗原抗体

hz-1302R GAD67  谷氨酸脱羧酶-67抗体

hz-5957R Styk1  丝氨酸/苏氨酸/酪氨酸激酶STYK1抗体

hz-0400R GAD65  谷氨酸脱羧酶-65抗体(C端）

hz-1776R GADD34  生长抑制DNA损伤基因34抗体

hz-1360R GADD45  生长抑制DNA损伤基因45抗体

hz-5904R GADD45B  生长抑制DNA损伤基因GADD45β抗体

hz-1361R GADD153/CHOP/DDIT3  GADD153抗体

hz-5177R phospho-GADD153 (Ser30)  磷酸化GADD153抗体

hz-5958R AF 4 protein  原癌基因AF4蛋白抗体

hz-0017M Galanin  神经节肽抗体

hz-5960R B MyB  转录因子MYB相关蛋白B抗体

hz-0721R Galectin 3  半乳糖凝集素3抗体

hz-3983R Galactose kinase/GALK1  半乳糖激酶1抗体

hz-1699R Galectin 9  半乳糖凝集素9抗体

hz-3984R GALT  磷酸半乳糖尿苷酸转移酶1抗体

hz-0154R GAP43  神经生长相关蛋白43

hz-5962R BORIS/CT27  肿瘤/睾丸抗原27抗体（高迁移率族蛋白）

hz-1641R phospho-GAP43(Ser41)  磷酸化神经生长相关蛋白43抗体

hz-5963R CDCA7L  细胞分裂周期相关蛋白JPO2抗体

hz-5964R ETS2  癌基因ETS2抗体

hz-0755R GAPDH  3-磷酸甘油醛脱氢酶（兔来源免疫组化用抗体）

hz-0835R GAPDH  3-磷酸甘油醛脱氢酶（兔来源免疫组化用抗体）

hz-5965R ETV7  转录因子ETV7抗体

hz-5966R LMO4  乳腺肿瘤自身抗原LMO4抗体

hz-0459R GAPDH  3-磷酸甘油醛脱氢酶（兔来源免疫组化用抗体）

hz-3795R GCDGP15/SABP  囊性组织液体蛋白15抗体