获取电话英文名称 DERL3
中文名称 内质网退化蛋白3抗体
别 名 C22orf14; Degradation in endoplasmic reticulum protein 3; DER 3; Der1 like domain family member 3; Der1 like protein 3; Der1-like protein 3; DER3; DERL 3; Derl3; DERL3_HUMAN; Derlin 3; Derlin 3 protein; Derlin-3; Derlin3; DERtrin 3; DERtrin-3; DERtrin3; IZP 6; IZP6; LLN 2; LLN2; MGC71803.
说 明 书 0.2ml
研究领域 信号转导 转运蛋白
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 内质网退化蛋白3抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DERL3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
内质网退化蛋白3抗体产品介绍 background:
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Function:
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.
Subcellular Location:
Endoplasmic reticulum membrane.
Tissue Specificity:
Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.
Similarity:
Belongs to the derlin family.
Gene ID:
91319
Database links:
Entrez Gene: 91319 Human
Entrez Gene: 614334 Cow
Entrez Gene: 70377 Mouse
Omim: 610305 Human
SwissProt: Q0P5E4 Cow
SwissProt: Q96Q80 Human
SwissProt: Q9D8K3 Mouse
Unigene: 593679 Human
Unigene: 275878 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
内质网退化蛋白3抗体
hz-0971PB chloramphenicol/BSA 氯霉素偶联牛血清白蛋白
hz-0971PA chloramphenicol/OVA 氯霉素偶联鸡卵白蛋白蛋白
hz-0972PB Gentamicin/BSA 庆大霉素偶联牛血清白蛋白
hz-0972PA Gentamicin/OVA 庆大霉素偶联鸡卵白蛋白
hz-0973PB Tetracycline/BSA 四环素偶联牛血清白蛋白
hzF-0972 Gentamicin/FITC 荧光素标记庆大霉素
hz-0973PA Tetracycline/OVA 四环素偶联鸡卵白蛋白
hz-0974PB Oxytetracycline/BSA 土霉素偶联牛血清白蛋白
hz-0974PA Oxytetracycline/OVA 土霉素偶联鸡卵白蛋白
hz-2037PK streptomycin/OVA 链霉素偶联血蓝蛋白
hz-2036PB Penicillin G/BSA 青霉素G偶联牛血清白蛋白
hz-2036PA Penicillin G/OVA 青霉素G偶联鸡卵白蛋白
hz-2037PB streptomycin/BSA 链霉素偶联牛血清白蛋白
hz-2037PA streptomycin/OVA 链霉素偶联鸡卵白蛋白
hz-2059PA Metronidazole/OVA 甲硝唑偶联鸡卵白蛋白
hz-2059PB Metronidazole/BSA 甲硝唑偶联牛血清白蛋白
hz-2129PK Morphine/KLH 吗啡与血蓝蛋白偶联物
hz-2059PK Metronidazole/KLH 甲硝唑偶联牛血蓝蛋白
hz-2129PB Morphine/BSA 吗啡与牛血清白蛋白偶联物
hz-2052P TRF(transferrin) 转铁蛋白
hz-2182PA Melamine/OVA 三聚氰胺偶联鸡卵白蛋白
hz-2182PB Melamine/BSA 三聚氰胺偶联牛血清白蛋白
hz-2182PBG Melamine/Bov IgG 三聚氰胺偶联牛IgG
hz-2252PK GABA/KLH γ1氨基丁酸偶联血蓝蛋白
hz-2252PB GABA/BSA γ1氨基丁酸偶联牛血清白蛋白
hz-1077P OCT2 (Octamer-binding transcription factor 2) 阳离子转运蛋白2抗原
六、标记蛋白质与多肽
编 号 名 称
hz-4560PB Taurine/BSA 牛磺酸偶联牛血清白蛋白（β-氨基乙磺酸）
hz-4606PB Gibberellins/BSA 赤霉素偶联牛血清白蛋白
hzF-0326P Bovine IgG/FITC 荧光素标记牛IgG
hzF-0789P Insulin Protein/FITC 荧光素标记猪胰岛素蛋白
