脑啡肽A抗体

英文名称    Dynorphin A    

中文名称    脑啡肽A抗体    

别    名    Beta neoendorphin dynorphin; Dyn A17; Dynorphin A; PDYN; Preprodynorphin; Proenkephalin B; PDYN_HUMAN; Dynorphin A(1-13); Dynorphin A(1-17); Dynorphin A(1-8) .    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  神经生物学  信号转导  细胞类型标志物      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Monkey,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 脑啡肽A抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    2kDa    

细胞定位    分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Dynamin 3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 ∑C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20∑C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ∑C.    

脑啡肽A抗体产品介绍    background:

The Proenkephalin precursor proteins are secreted proteins belonging to the opioid neuropeptide precursor family. The Proenkephalin proteins are proteolytically processed to form active secreted opioid peptides, which function as ligands for the ⅹ-type of opioid receptor. The Proenkephalin A precursor contains Synenkephalin, Leu-enkephalin and Met-enkephalin processed active peptides, while the Proenkephalin B precursor contains beta-neoendorphin, Dynorphin, Leumorphin, Leu-enkephalin and rimorphin processed active peptides. beta-endorphin and Met-enkephalin are endogenous opiates, while ACTH is crucial for adrenal gland stimulation to release cortisol. MSH increases melanin production in melanocytes, which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP kinase and PI 3-kinase pathways.

Function:
Dynorphins are a class of peptides produced by many different populations of neurons, which has some opiate like activity. It is thus classed as an endogenous opioid peptide. The dynorphins, which include dynorphin A, dynorphin B, alpha and beta neoendorphin, and big dynorphin, are all the products of a single gene, 'preprodynorphin'. Dynorphin is produced in many different parts of the brain, including the hypothalamus, the hippocampus and the spinal cord, and has many different physiological actions, depending upon its site of production. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. As such, it may help some individuals against addiction. Blocking dynorphin may help alleviate depression.

Subcellular Location:
Secreted

Post-translational modifications:
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

DISEASE:
Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. 

Similarity:
Belongs to the opioid neuropeptide precursor family.     

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