细胞质分裂付出蛋白2抗体

英文名称    DOCK2    

中文名称    细胞质分裂付出蛋白2抗体    

别    名    Dedicator of cyto kinesis 2; Dedicator of cytokinesis 2; Dedicator of cytokinesis protein 2; DOCK 2; FLJ46592; KIAA0209; DOCK2_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  信号转导  干细胞  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 细胞质分裂付出蛋白2抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    212kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DOCK2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞质分裂付出蛋白2抗体产品介绍    background:

The DOCK2 gene encodes dedicator of cytokinesis 2 (DOCK 2), a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. DOCK 2 participates in the cytoskeletal rearrangements that are required for lymphocyte migration in response of chemokines. This peripheral membrane protein activates Rac 1 and Rac 2 small GTPases, while presumably acting as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK 2 may also participate in IL-2 transcriptional activation through the activation of Rac 2. DOCK 2 contains one DHR-1 (CZH-1) domain, one DHR-2 (CZH-2) domain and one SH3 domain. The DHR-2 domain is a putative GEF activity mediator. The DOCK 2 protein also co-localizes with F-Actin, and demonstrates expression in several human tissues, with the highest levels observed in peripheral blood leukocytes, thymus, spleen and liver. 

Function:
DOCK2 (dedicator of cytokinesis 2) is a hematopoietic cell-specific protein that participates in the cytoskeletal rearrangements required for lymphocyte migration in response to chemokines. DOCK2 activates the small GTPases RAC1 and RAC2 and may also be involved in IL2 transcriptional activation via the activation of RAC2.

Subunit:
Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z. 

Subcellular Location:
Intracytoplasmic membrane. Peripheral membrane protein. Note=Colocalizes with F-actin.

Tissue Specificity:
Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.    

细胞质分裂付出蛋白2抗体

hz-0604P galectin 9   半乳糖凝集素9（抗原）

hz-0830P Oct-4  胚胎干细胞关键蛋白(多肽)

hz-0026P OPN(osteopontin)  骨桥蛋白（抗原）

hz-0740P P16/CDKN2A (Cyclin-dependent kinase inhibitor-2A)  抑癌基因p16（抗原）

hz-0741P p21/WAF1/CIP1   p21 核分裂抑制因子之一（抗原）

hz-0742P p27 (cyclin-dependent kinase inhibitor 1B)  p27(抗原)

hz-0723P P63 protein  P63 肿瘤抑制基因（抗原）

hz-0431P OPG(Osteoprotegerin)  护骨素(多肽抗原)

hz-0747P OPGL (Osteoprotegerin ligand)  骨保护蛋白配体(抗原)

hz-0427P P311 protein  增生性瘢痕相关蛋白（抗原）

hz-0769P PARP(poly ADP-ribose polymerase)  多腺苷二磷酸多聚酶抗原

hz-0270P Visfatin-1 (PBEF1)(NT) Human  内脂素/内脏脂肪素（人：N端多肽）、内脏脂肪素、 又称：前B细胞克隆增强因子、内肥素、腹脂素

hz-0272P Visfatin-1 (PBEF1)(NT)   内脂素/内脏脂肪素

hz-0273P PBEF (CT)  内脂素/B细胞克隆增强因子

hz-0731P PEDF (pigment epithelium-derived factor)  色素上皮源性因子(多肽抗原）

hz-0739P PAP2c (Phosphatidic acid phosphatase 2c)  磷脂酸磷酸酶2C（抗原）

hz-0689P PEPT1 (Peptide-transporters 1)  肠道肽转运蛋白(小肽转运蛋白)多肽

hz-0748P PTEN/MMAC1  一种肿瘤抑制基因抗原

hz-0420P PIBF(progesterone induced blocking factor)  孕激素诱导阻断因子(抗原)

hz-0665P PIWIL1(piwi-like 1)  piwi 样1蛋白(抗原)

hz-0530P PPAR Gamma (peroxisome proliferator-activated receptor-gamma)  过氧化酶活化增生受体γ（抗原）

hz-0490P PP2Ac  蛋白磷酸酶4(抗原)

hz-0378P Runx3  一种新发现的抑癌基因(抗原)

hz-0278P RRAD (Ras-related associated with diabetes )  RRAD(多肽抗原)

hz-0783P SDF-1/CXCL12 (stromal cell derived factor-1)  基质细胞衍生因子-1(抗原)

hz-0211P shank1(SH3 and multiple anleyrin repead domins protein 1)  shank1多肽抗原

hz-0444P slc22A17 (solute carrier famili 22)  溶质转运蛋白家族22成员17(多肽抗原)

hz-0496P SLC24A5 (solute carrier family 24, mhzber 5)  可溶性载质转运蛋白SLC24A5（抗原）

hz-0473P solute carrier family 1  溶质携带物家族-1(抗原)

hz-0478P SLC6A4 (solute carrier family 6)  钾依赖钠钙交换蛋白6(抗原)

hz-0615P Survivin  细胞凋亡抑制因子的一种（抗原）

hz-0726P BIRC5/Survivin variant  细胞凋亡抑制因子4（抗原）

hz-0635P SSA/RO (ribonucleoprotein complex,RNP)  核糖核蛋白抗原RO/SSA(抗原)