阅读障碍相关蛋白DLX2抗体

英文名称    DYX2/KIAA0319    

中文名称    阅读障碍相关蛋白DLX2抗体    

别    名    DLX 2; DLX2; DYLX 2; DYLX2; Dyslexia susceptibility 2; Dyslexia-associated protein KIAA0319 DYX 2; DYX2; K0319_HUMAN; Kiaa0319; MGC176717.    

说 明 书    0.2ml      

研究领域    细胞生物  神经生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 阅读障碍相关蛋白DLX2抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    116kDa    

细胞定位    细胞浆 细胞膜 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DYX2/KIAA0319    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

阅读障碍相关蛋白DLX2抗体产品介绍    background:

DYX2 is a 1072 amino acid single-pass transmembrane protein that contains one MANSC domain and two PKD (Polycystic Kidney Disease) domains, which are usually found in the extracellular regions of proteins and are involved in protein-protein interactions. In DYX2, it is likely that its PKD domains mediate the interaction between neurons and glial fibers during neuronal migration. When overexpressed, this plasma membrane protein colocalizes with EEA1 (early endosome antigen 1) in large intracellular vesicles, suggesting that it is endocytosed and recycled. DYX2 is highly expressed in brain cortex, cerebellum, amygdala, putamen and hippocampus. Defects in the gene encoding DYX2 may be the cause of dyslexia type 2, a relatively common disorder that is characterized by reading performance impairment in the absence of sensory or neurologic disability. There are three isoforms of DYX2 that are produced as a result of alternative splicing events

Function:
Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.

Subunit:
Homodimer. Interacts with AP2M1; required for clathrin-mediated endocytosis. 

Subcellular Location:
Cell membrane. Early endosome membrane. Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted.

Tissue Specificity:
Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum.

Post-translational modifications:
N-glycosylated.
O-glycosylated.
Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus.

DISEASE:
Defects in KIAA0319 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. Note=A lower expression is associated with the risk haplotype    

阅读障碍相关蛋白DLX2抗体

hz-1502P CXCL10/IP-10  CXCL10趋化因子10/干扰素诱导蛋白10抗原

hz-0279P VEGF(Vascular endothelial growth factor)  血管内皮生长因子（多肽抗原）

hz-0527P CD10/CALLA (Neutral Endopeptidase)  CD10抗原

hz-0354P ZCWCC1(Zinc finger CW-type coiled-coil domain protein 1)  ZCWCC1抗原

hz-0579P CD105/Endoglin/TGF- Beta receptor  CD105/转化生长因子β受体抗原

hz-1309P CD138/Syndecan-1  多配体蛋白聚糖1抗原

hz-1618P CD146/MCAM  黑色素瘤细胞粘附分子CD146抗原

hz-1383P ANPEN/CD13(Aminopeptidase N)  氨肽酶N抗原

hz-1192P CD14(cluster of differentiation antigen 14)  CD14/内毒素受体抗原

hz-1297P CD28  CD28抗原

hz-1251P CD166/ALCAM(activated leukocyte celladhesion molecule)  活化白细胞粘附分子抗原

hz-1482P CD177/NB1 peptide  嗜中性粒细胞抗原CD177抗原

hz-0528P CD24  CD24抗原

hz-0512P CD2AP (CD2-associated protein)  白细胞分化抗原CD2AP

hz-2042P CD33 peptide(human)  CD33抗原（人）

hz-1514P CD33/Siglec-3(mouse ret)  CD33抗原(大、小鼠）

hz-2038P CD34  CD34抗原（细胞表面的唾液粘蛋白）

hz-0979P CD38(mouse, rat)  CD38多肽（小鼠、大鼠）

hz-0980P CD38(human)  CD38抗原（人）

hz-1100P CD36  CD36（多肽）

hz-1520P CD7  CD7抗原

hz-1286P CD40L(CD40 Ligand/TNFSF5/CD154)  CD40L抗原

hz-0521P CD44  CD44抗原 (多肽抗原)

Y-0206 Argireline peptide   抗皱寡肽-1/六胜肽-3/阿基瑞林/乙酰六胜肽-3

Y-0207 GHRP-2 Acetate peptide(Growth hormone-releasing peptides 2)  醋酸促生长激素释放肽2

Y-0208 GHRP-6 Acetate peptide(Growth hormone-releasing peptides 6)  醋酸促生长激素释放肽6

Y-0209 Matrixyl Acetate  五胜肽/美容肽—M肽

Y-0210 MT-II(Melanotan II Acetate)  醋酸美拉诺坦II

Y-0211 Pentapeptide-3/Leuphasyl  五胜肽

Y-0212 PT141(Brhzelanotide PT-141)  雌性激素肽

hz-0522P CD45  CD45(白细胞共同抗原)

hz-1539P CD46/MCP(mhzbrane cofactor protein)rat, mouse  膜辅蛋白/内源性辅助因子活性蛋白抗原

hz-1113P CD5  CD5 多肽抗原

hz-1258P ICAM-2/CD102(intercellular adhesion molecules-2)  细胞间粘附分子-2抗原