英文名称 DGCR6
中文名称 无胸腺症相关蛋白DGCR6/迪格奥尔格综合征关键基因6抗体
别 名 DGCR 6; DGCR6 protein; DiGeorge syndrome critical region 6; DiGeorge syndrome critical region gene 6; DGCR6_HUMAN.
说 明 书 0.2ml
研究领域 细胞生物 发育生物学 神经生物学 干细胞
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 无胸腺症相关蛋白DGCR6/迪格奥尔格综合征关键基因6抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DGCR6 (112-180aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
无胸腺症相关蛋白DGCR6/迪格奥尔格综合征关键基因6抗体产品介绍 background:
Neural crest cell migration to the third and fourth pharyngeal pouches is a critical step in the structural formation of organs that are affected in DiGeorge syndrome. DGCR6 (DiGeorge syndrome critical region 6) is a nuclear protein that plays a role in neural crest cell migration and is located at the DiGeorge syndrome critical region (DGCR) on chromosome 22. Expressed ubiquitously with highest levels in heart, liver and skeletal muscle, DGCR6 shares high homology with the Drosophila gonadal (gdl) protein and with human Laminin ?1, both of which are involved in early tissue development. The gene encoding DGCR6, along with other DGCR genes, is deleted in DiGeorge syndrome; a developmental disorder characterized by improper facial, cardiac and palate formation. Upregulation of DGCR6 is implicated in lung and colon adenocarcinomas, as well as in Burkitt抯 lymphoma and lymphocytes transformed by EBV. Due to a duplication of the ancestral DGCR6 locus, there are two functional, highly homologous copies of the DGCR6 gene (designated DGCR6 and DGCR6L) on chromosome 22.
Function:
DGCR6 shares homology with the Drosophila melanogaster gonadal protein, which participates in gonadal and germ cell development, and with the human laminin gamma-1 chain, which upon polymerization with alpha- and beta-chains forms the laminin molecule. Laminin binds to cells through interaction with a receptor and has functions in cell attachment, migration, and tissue organization during development. This protein could be a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome.
Subcellular Location:
Nucleus. Note=Predominantly nuclear.
Tissue Specificity:
Found in all tissues examined with highest expression in liver, heart and skeletal muscle. Lower levels in pancreas and placenta. Weak expression in brain.
Similarity:
Belongs to the gonadal family.
无胸腺症相关蛋白DGCR6/迪格奥尔格综合征关键基因6抗体
hz-0112P APP695-770 (Amyloid protein precursor) 淀粉样肽前体蛋白(多肽抗原)
hz-0499P Neuroprotective peptide/Gly-HN(Nuclear-encoded Humanin [HN(N)] Gly14) 神经保护肽
Y-0158 Amylin(1-37) amide 糖尿病相关肽/胰岛淀粉样肽
hz-1053P CCP peptide (cyclic citrullinated peptide,CCP) 瓜氨酸环肽
hz-0616P CCP peptide (cyclic citrullinated peptide,CCP) 瓜氨酸环肽
hz-4536P Streptococcus suis 2 (Cell protein) 2型猪链球菌菌体蛋白
hz-0038P GLP-1(Glucagon-like peptide-1)(7-36)peptide 胰高血糖素样肽-1(多肽)
hz-0995P ADM (Adrenomedullin)ProAM-N20 Rat, human, mo, pig, dog, bov 肾上腺髓质素蛋白(N端20肽)
hz-1158P AGEs 晚期糖基化终末产物AGEs
hz-1158Phz AGEs control article(advanced glycosylation end products control article) 晚期糖基化终末产物蛋白对照品
hz-0954P ET-1(Endothelin-1) 内皮素-1(蛋白多肽 活性蛋白)
Y-0108 GRGDS peptide 粘附多肽GRGDS
hz-0601P PACAP(1-38 Peptide) 腺苷酸环化酶激活肽 1-38(全蛋白)
hz-0380P MBP(Myelin Basic Protein, MBP 68-86) 髓鞘碱性蛋白(多肽抗原)
hz-2046P Bursin 囊素三肽/三肽囊素/鸡法氏囊三肽
hz-0383P NPY ( Neuropeptide Y)1-36 神经肽 Y(1-36多肽)
Y-0067 Leupeptin 亮抑酶肽
hz-0011P GRP( Gastrin Releasing Peptide ) 促胃泌素释放肽(抗原)
P0006 BSA(标准) 牛血清白蛋白(标准)
hz-2031P MBP (Myelin Basic Protein, Rat)peptide 髓鞘碱性蛋白(多肽)大鼠
hz-0426P MOG35-55 (myelin oligo-dendrocyte glycoprotein-MOG) 髓鞘少树突胶质细胞糖蛋白(活性多肽)
hz-0014P IGF-I( Insulin-like Growth Factor-I ) 胰岛素样生长因子-I(抗原)
hz-0077P VIP (Vasoactive Intestinal peptide) 血管活性肠肽
hz-0015P IGF-II( Insulin-like Growth Factor-II ) 胰岛素样生长因子-II(抗原)
hz-0392P TP-5(Thymopentin) 胸腺五肽
hz-0017P Galanin 神经节肽
hz-0841P GLP-2(Glucagon-like peptide-2) 胰高血糖素样肽-2蛋白
hz-0039P ADNP (NAP) (Activity-dependent Neuroprotective protein ) 活性依赖的神经保护肽(抗原)
hz-0094P AACT(Alpha-1-Anti-chymotrypsin) α-1抗胰糜蛋白酶
hz-2179P AACT protein(Alpha chymotrypsin protein) 胰糜蛋白酶
hz-0443P ACTH (Adrenorticotrophin hormons)(1-39) 促肾上腺皮质激素(1-39)(抗原)
Y-0133 ADM 1-52/AM 1-52 (Adrenomedullin 1-52) 肾上腺髓质素(1-52)
hz-0311PK Biotin/KLH 生物素偶联血蓝蛋白
无胸腺症相关蛋白DGCR6/迪格奥尔格综合征关键基因6抗体 多少钱?
CST抗体/抗原的应用资料有吗?
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CST货号hz-11722R货期是多久?
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