双氧化酶2/甲状腺氧化酶2抗体

英文名称    DUOX2    

中文名称    双氧化酶2/甲状腺氧化酶2抗体    

别    名    Dual oxidase 2; Dual oxidase2; DUOX2; DUOX2_HUMAN; Large NOX 2; LNOX2; Long NOX 2; NADH/NADPH thyroid oxidase p138 tox; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; NOXEF2; p138 thyroid oxidase; P138 TOX; THOX2; Thyroid oxidase 2.    

说 明 书    0.2ml      

研究领域    细胞生物  神经生物学  细胞膜蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500双氧化酶2/甲状腺氧化酶2抗体 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    173kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DUOX2 (501-600aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

双氧化酶2/甲状腺氧化酶2抗体产品介绍    background:

Dual oxidase 2 (DUOX2), also designated NADPH thyroid oxidase 2, p138 thyroid oxidase or large NOX2, localizes to the apical membrane of epithelial cells. DUOX1, also designated NADPH thyroid oxidase or large NOX1, and DUOX2 are multi-pass membrane proteins predominantly expressed in thyrocytes, tracheal surface epithelial cells as well as thyroid, colon, duodenum, trachea and bronchium. DUOX1 and DUOX2 generate hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. In mucosa, DUOX proteins are involved in thyroid hormone biosynthesis and lactoperoxidase-mediated antimicrobial defense. Defects in the gene encoding for DUOX2 cause congenital hypothyroidism (CH), a disorder characterized by a defect in hydrogen peroxide production in the thyroid gland.

Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.

Subunit:
Interacts with TXNDC11, TPO and CYBA.

Subcellular Location:
Apical cell membrane. Localizes to the apical membrane of epithelial cells.

Tissue Specificity:
Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis.

Post-translational modifications:
N-glycosylated.

DISEASE:
Defects in DUOX2 are a cause of thyroid dyshormonogenesis 6 (TDH6) [MIM:607200]. A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.    

双氧化酶2/甲状腺氧化酶2抗体

hz-0375R-PE-hzY5 Rabbit Anti-Guinea pig IgM/PE-CY5  PE-CY5标记的兔抗豚鼠IgM

hz-0375R-APhz Rabbit Anti-Guinea pig IgM/APC  APC标记的兔抗豚鼠IgM

hz-0375R-AF350 Rabbit Anti-Guinea pig IgM/Alexa Fluor 350  Alexa Fluor 350标记的兔抗豚鼠IgM

hz-0375R-AF488 Rabbit Anti-Guinea pig IgM/Alexa Fluor 488  Alexa Fluor 488标记的兔抗豚鼠IgM

hz-0375R-AF555 Rabbit Anti-Guinea pig IgM/Alexa Fluor 555  Alexa Fluor 555标记的兔抗豚鼠IgM

hz-0375R-AP Rabbit Anti-Guinea pig IgM/AP  碱性磷酸酶（AP）标记的兔抗豚鼠IgM

hz-0375R-Gold Rabbit Anti-Guinea pig IgM/Gold  胶体金标记的兔抗豚鼠IgM

hz-0375R-AF647 Rabbit Anti-Guinea pig IgM/Alexa Fluor 647  Alexa Fluor 647标记的兔抗豚鼠IgM

hz-0375R-PE-hzy5.5 Rabbit Anti-Guinea pig IgM/PE-Cy5.5  PE-Cy5.5标记的兔抗豚鼠IgM

hz-0375R-PE-hzy7 Rabbit Anti-Guinea pig IgM/PE-Cy7  PE-Cy7标记的兔抗豚鼠IgM

hz-0375R-hzy5.5 Rabbit Anti-Guinea pig IgM/Cy5.5  Cy5.5标记的兔抗豚鼠IgM

hz-0375R-hzy7 Rabbit Anti-Guinea pig IgM/Cy7  Cy7标记的兔抗豚鼠IgM

hz-0375R-PE Rabbit Anti-Guinea pig IgM/PE  PE标记的兔抗豚鼠IgM

hz-0375R-PE-hzy3 Rabbit Anti-Guinea pig IgM/PE-Cy3  PE-Cy3标记的兔抗豚鼠IgM

hz-0375R-RBIThz Rabbit Anti-Guinea pig IgM/RBITC  罗丹明标记的兔抗豚鼠IgM

hz-0375R-FIThz Rabbit Anti-Guinea pig IgM/FITC  FITC标记的兔抗豚鼠IgM

hz-0308R-FIThz Rabbit Anti-horse IgG/FITC  FITC标记的兔抗马IgG

hz-0308R-Gold Rabbit Anti-horse IgG/Gold  胶体金标记的兔抗马IgG

hz-0308R-RBIThz Rabbit Anti-horse IgG/RBITC  罗丹明标记的兔抗马IgG

hz-0308R-hzy3 Rabbit Anti-horse IgG/Cy3  Cy3标记的兔抗马IgG

hz-0308R-hzy5 Rabbit Anti-horse IgG/Cy5  Cy5标记的兔抗马IgG

hz-0308R-hzy5.5 Rabbit Anti-horse IgG/Cy5.5  Cy5.5标记的兔抗马IgG

hz-0308R-hzy7 Rabbit Anti-horse IgG/Cy7  Cy7标记的兔抗马IgG

hz-0308R-PE Rabbit Anti-horse IgG/PE  PE标记的兔抗马IgG

hz-0308R-PE-hzy3 Rabbit Anti-horse IgG/PE-Cy3  PE-Cy3标记的兔抗马IgG

hz-0308R-PE-hzY5 Rabbit Anti-horse IgG/PE-CY5  PE-CY5标记的兔抗马IgG

hz-0308R-APhz Rabbit Anti-horse IgG/APC  APC标记的兔抗马IgG

hz-0308R-AF350 Rabbit Anti-horse IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗马IgG

hz-0308R-AF488 Rabbit Anti-horse IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗马IgG

hz-0308R-AF555 Rabbit Anti-horse IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗马IgG