双氧化酶1/甲状腺氧化酶1抗体

英文名称    DUOX1    

中文名称    双氧化酶1/甲状腺氧化酶1抗体    

别    名    Dual oxidase 1; Dual oxidase 1 precursor; DUOX1; EC 1.11.1; EC 1.6.3.1; Flavoprotein NADPH oxidase; Large NOX 1; LNOX1; Long NOX 1; MGC138840; MGC138841; NADPH thyroid oxidase 1; Nicotinamide adenine dinucleotide phosphate oxidase; NOXEF1; THOX1; Thyroid oxidase 1; DUOX1_HUMAN.    

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  神经生物学  信号转导  生长因子和激素      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 双氧化酶1/甲状腺氧化酶1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    175kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DUOX1 (1-100aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

双氧化酶1/甲状腺氧化酶1抗体产品介绍    background:

Dual oxidase 1 (DUOX1), a homolog of glycoprotein p91Phox, is expressed in airway epithelium and generates reactive oxygen species (ROS). DUOX1 is a multi-pass membrane protein predominantly expressed in thyrocytes and tracheal surface epithelial cells, as well as thyroid, trachea and bronchium. DUOX1 generates hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. It is also involved in thyroid hormone synthesis and lactoperoxidase-mediated antimicrobial defense in mucosa. DUOX1, which also plays a role in mucin expression, is widely expressed in fetal tissues.

Function:
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene (from EntrezGene).

Subunit:
Interacts with TXNDC11, TPO and CYBA.

Subcellular Location:
Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.

Tissue Specificity:
Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.    

双氧化酶1/甲状腺氧化酶1抗体

hz-0370R-APhz Rabbit Anti-Goat IgM/APC  APC标记的兔抗羊IgM

hz-0370R-AF350 Rabbit Anti-Goat IgM/Alexa Fluor 350  Alexa Fluor 350标记的兔抗羊IgM

hz-0370R-AF488 Rabbit Anti-Goat IgM/Alexa Fluor 488  Alexa Fluor 488标记的兔抗羊IgM

hz-0370R-AF555 Rabbit Anti-Goat IgM/Alexa Fluor 555  Alexa Fluor 555标记的兔抗羊IgM

hz-0370R-AF647 Rabbit Anti-Goat IgM/Alexa Fluor 647  Alexa Fluor 647标记的兔抗羊IgM

hz-0370R-PE-hzy5.5 Rabbit Anti-Goat IgM/PE-Cy5.5  PE-Cy5.5标记的兔抗羊IgM

hz-0370R-PE-hzy7 Rabbit Anti-Goat IgM/PE-Cy7  PE-Cy7标记的兔抗羊IgM

hz-0370R-RBIThz Rabbit Anti-Goat IgM/RBITC  罗丹明标记的兔抗羊IgM

hz-0370R-FIThz Rabbit Anti-Goat IgM/FITC  FITC标记的兔抗羊IgM

hz-0358R-FIThz Rabbit Anti-Guinea pig IgG/FITC  FITC标记的兔抗豚鼠IgG

hz-0358R-AF555 Rabbit Anti-Guinea pig IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗豚鼠IgG

hz-0358R-AF647 Rabbit Anti-Guinea pig IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗豚鼠IgG

hz-0358R-PE-hzy5.5 Rabbit Anti-Guinea pig IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗豚鼠IgG

hz-0358R-PE-hzy7 Rabbit Anti-Guinea pig IgG/PE-Cy7  PE-Cy7标记的兔抗豚鼠IgG

hz-0358R-RBIThz Rabbit Anti-Guinea pig IgG/RBITC  罗丹明标记的兔抗豚鼠IgG

hz-0358R-hzy3 Rabbit Anti-Guinea pig IgG/Cy3  Cy3标记的兔抗豚鼠IgG

hz-0358R-hzy5 Rabbit Anti-Guinea pig IgG/Cy5  Cy5标记的兔抗豚鼠IgG

hz-0358R-hzy5.5 Rabbit Anti-Guinea pig IgG/Cy5.5  Cy5.5标记的兔抗豚鼠IgG

hz-0358R-hzy7 Rabbit Anti-Guinea pig IgG/Cy7  Cy7标记的兔抗豚鼠IgG

hz-0358R-PE Rabbit Anti-Guinea pig IgG/PE  PE标记的兔抗豚鼠IgG

hz-0358R-PE-hzy3 Rabbit Anti-Guinea pig IgG/PE-Cy3  PE-Cy3标记的兔抗豚鼠IgG

hz-0358R-PE-hzY5 Rabbit Anti-Guinea pig IgG/PE-CY5  PE-CY5标记的兔抗豚鼠IgG

hz-0358R-APhz Rabbit Anti-Guinea pig IgG/APC  APC标记的兔抗豚鼠IgG

hz-0358R-AF350 Rabbit Anti-Guinea pig IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗豚鼠IgG

hz-0358R-AF488 Rabbit Anti-Guinea pig IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗豚鼠IgG

hz-0358R-AP Rabbit Anti-Guinea pig IgG/AP  碱性磷酸酶（AP）标记的兔抗豚鼠IgG

hz-0358R-HRP Rabbit Anti-Guinea pig IgG/HRP  辣根过氧化物酶标记的兔抗豚鼠IgG

hz-0358R-Gold Rabbit Anti-Guinea pig IgG/Gold  胶体金标记的兔抗豚鼠IgG

hz-0358R-Bio Rabbit Anti-Guinea pig IgG/Bio  生物素标记的兔抗豚鼠IgG

hz-0375R-HRP Rabbit Anti-Guinea pig IgM/HRP  辣根过氧化物酶标记的兔抗豚鼠IgM

hz-0375R-Bio Rabbit Anti-Guinea pig IgM/Bio  生物素标记的兔抗豚鼠IgM

hz-0375R-hzy3 Rabbit Anti-Guinea pig IgM/Cy3  Cy3标记的兔抗豚鼠IgM

hz-0375R-hzy5 Rabbit Anti-Guinea pig IgM/Cy5  Cy5标记的兔抗豚鼠IgM