获取电话英文名称 DNAI1 + 2
中文名称 轴丝中链动力蛋白抗体
别 名 DNAI1; DNAI1 / 2; DNAI1/2; DNAI 1/2; DNAI 1 + 2; Axonemal dynein intermediate chain 1; Axonemal dynein intermediate chain 2; CILD 1; CILD1; DNAI 1; DNAI 2; DNAI1_HUMAN; Dynein axonemal intermediate chain 1; Dynein axonemal intermediate polypeptide 1; Dynein axonemal intermediate polypeptide 2; Dynein intermediate chain 1 axonemal; Dynein intermediate chain 1 cytosolic; Dynein intermediate chain 1, axonemal; Dynein intermediate chain 2 axonemal; Dynein intermediate chain 2 cytosolic; Dynein intermediate chain DNAI1; ICS; MGC26204; PCD.
说 明 书 0.2ml
研究领域 神经生物学 信号转导 细胞粘附分子 细胞骨架
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 轴丝中链动力蛋白抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 79kDa
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DNAI1/2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
轴丝中链动力蛋白抗体产品介绍 background:
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008].
Function:
Part of the dynein complex of respiratory cilia.
Subunit:
Consists of at least two heavy chains and a number of intermediate and light chains.
Subcellular Location:
Cytoplasm, cytoskeleton, cilium axoneme.
DISEASE:
Defects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1) [MIM:244400]. CILD1 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
Defects in DNAI1 are the cause of Kartagener syndrome (KTGS) [MIM:244400]. KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera).
Similarity:
Belongs to the dynein intermediate chain family.
Contains 5 WD repeats.
轴丝中链动力蛋白抗体
hz-0326G-hzy7 Goat Anti-Bovine IgG/Cy7 Cy7标记的羊抗牛IgG
hz-0326G-PE Goat Anti-Bovine IgG/PE PE标记的羊抗牛IgG
hz-0326G-PE-hzy3 Goat Anti-Bovine IgG/PE-Cy3 PE-Cy3标记的羊抗牛IgG
hz-0326G-PE-hzY5 Goat Anti-Bovine IgG/PE-CY5 PE-CY5标记的羊抗牛IgG
hz-0326G-APhz Goat Anti-Bovine IgG/APC APC标记的羊抗牛IgG
hz-0326G-AF350 Goat Anti-Bovine IgG/Alexa Fluor 350 Alexa Fluor 350标记的羊抗牛IgG
hz-0326G-AF488 Goat Anti-Bovine IgG/Alexa Fluor 488 Alexa Fluor 488标记的羊抗牛IgG
hz-0326G-AF555 Goat Anti-Bovine IgG/Alexa Fluor 555 Alexa Fluor 555标记的羊抗牛IgG
hz-0326G-AF647 Goat Anti-Bovine IgG/Alexa Fluor 647 Alexa Fluor 647标记的羊抗牛IgG
hz-0326G-PE-hzy5.5 Goat Anti-Bovine IgG/PE-Cy5.5 PE-Cy5.5标记的羊抗牛IgG
hz-0326G-PE-hzy7 Goat Anti-Bovine IgG/PE-Cy7 PE-Cy7标记的羊抗牛IgG
hz-0326G-RBIThz Goat Anti-Bovine IgG/RBITC 罗丹明标记的羊抗牛IgG
hz-0326G-FIThz Goat Anti-Bovine IgG/FITC FITC标记的羊抗牛IgG
hz-0326G-Gold Goat Anti-Bovine IgG/Gold 胶体金标记的羊抗牛IgG
hz-0326G-AP Goat Anti-Bovine IgG/AP 碱性磷酸酶（AP）标记的羊抗牛IgG
hz-0326G-hzy5.5 Goat Anti-Bovine IgG/Cy5.5 Cy5.5标记的羊抗牛IgG
hz-0326G-HRP Goat Anti-Bovine IgG/HRP 辣根过氧化物酶标记的羊抗牛IgG
hz-0326G-Bio Goat Anti-Bovine IgG/Bio 生物素标记的羊抗牛IgG
hz-0296G-Bio Goat Anti-Mouse IgG/Bio 生物素标记的羊抗小鼠IgG
hz-0296G-hzy3 Goat Anti-Mouse IgG/Cy3 Cy3标记的羊抗小鼠IgG
hz-0296G-hzy5 Goat Anti-Mouse IgG/Cy5 Cy5标记的羊抗小鼠IgG
hz-0296G-hzy5.5 Goat Anti-Mouse IgG/Cy5.5 Cy5.5标记的羊抗小鼠IgG
hz-0296G-hzy7 Goat Anti-Mouse IgG/Cy7 Cy7标记的羊抗小鼠IgG
hz-0296G-PE Goat Anti-Mouse IgG/PE PE标记的羊抗小鼠IgG
hz-0296G-PE-hzy3 Goat Anti-Mouse IgG/PE-Cy3 PE-Cy3标记的羊抗小鼠IgG
hz-0296G-PE-hzY5 Goat Anti-Mouse IgG/PE-CY5 PE-CY5标记的羊抗小鼠IgG
hz-0296G-APhz Goat Anti-Mouse IgG/APC APC标记的羊抗小鼠IgG
hz-0296G-AF350 Goat Anti-Mouse IgG/Alexa Fluor 350 Alexa Fluor 350标记的羊抗小鼠IgG
hz-0296G-AF488 Goat Anti-Mouse IgG/Alexa Fluor 488 Alexa Fluor 488标记的羊抗小鼠IgG
hz-0296G-AF555 Goat Anti-Mouse IgG/Alexa Fluor 555 Alexa Fluor 555标记的羊抗小鼠IgG
hz-0296G-AF647 Goat Anti-Mouse IgG/Alexa Fluor 647 Alexa Fluor 647标记的羊抗小鼠IgG
hz-0296G-PE-hzy5.5 Goat Anti-Mouse IgG/PE-Cy5.5 PE-Cy5.5标记的羊抗小鼠IgG
hz-0296G-PE-hzy7 Goat Anti-Mouse IgG/PE-Cy7 PE-Cy7标记的羊抗小鼠IgG
hz-0296G-AP Goat Anti-Mouse IgG/AP 碱性磷酸酶（AP）标记的羊抗小鼠IgG
