无胸腺症关键蛋白6样抗体（迪格奥尔格综合征）

英文名称    DGCR6L    

中文名称    无胸腺症关键蛋白6样抗体（迪格奥尔格综合征）    

别    名    DGC6L_HUMAN; DGCR6L; DiGeorge syndrome critical region 6-like protein; Protein DGCR6L.    

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  免疫学  神经生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 无胸腺症关键蛋白6样抗体（迪格奥尔格综合征）（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    25kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DGCR6L    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

无胸腺症关键蛋白6样抗体（迪格奥尔格综合征）产品介绍    background:

Neural crest cell migration to the third and fourth pharyngeal pouches is a critical step in the structural formation of organs that are affected in DiGeorge syndrome. DGCR6 (DiGeorge syndrome critical region 6) is a nuclear protein that plays a role in neural crest cell migration and is located at the DiGeorge syndrome critical region (DGCR) on chromosome 22. Expressed ubiquitously with highest levels in heart, liver and skeletal muscle, DGCR6 shares high homology with the Drosophila gonadal (gdl) protein and with human Laminin-1, both of which are involved in early tissue development. The gene encoding DGCR6, along with other DGCR genes, is deleted in DiGeorge syndrome; a developmental disorder characterized by improper facial, cardiac and palate formation. Upregulation of DGCR6 is implicated in lung and colon adenocarcinomas, as well as in Burkitt’s lymphoma and lymphocytes transformed by EBV. Due to a duplication of the ancestral DGCR6 locus, there are two functional, highly homologous copies of the DGCR6 gene (designated DGCR6 and DGCR6L) on chromosome 22.

Function:
May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.

Subcellular Location:
Nucleus. Predominantly nuclear.

Tissue Specificity:
Widely expressed in fetal and adult tissues. Highest expression in liver, heart and skeletal muscle. Lower levels in pancreas and placenta. Weak expression in brain.

Similarity:
Belongs to the gonadal family.     

无胸腺症关键蛋白6样抗体（迪格奥尔格综合征）

hz-0310Gs Goat anti-Chicken IgG whole serum  羊抗鸡IgG抗血清

hz-0297Ms Mouse anti-human IgG ascites  小鼠抗人IgG腹水

hz-0345Ms Mouse anti-human IgM ascites  小鼠抗人IgM腹水

hz-0294Ms Mouse anti-Goat IgG ascites  小鼠抗羊IgG腹水

hz-0295Ms Mouse anti-rabbit IgG ascites  小鼠抗兔IgG腹水

hz-0293Ms Mouse anti-rat IgG ascites  小鼠抗大鼠IgG腹水

hz-0326Ms Mouse anti-Bovine IgG ascites  小鼠抗牛IgG腹水

hz-0312Rs Rabbit anti-Avidin whole serum  兔抗亲和素抗血清

hz-0311Rs Rabbit anti-Biotin whole serum  兔抗生物素抗血清

hz-0326Rs Rabbit anti-Bovine IgG whole serum  兔抗牛IgG抗血清

hz-0327Rs Rabbit anti-Bovine IgM whole serum  兔抗牛IgM抗血清

hz-0310Rs Rabbit anti-chicken IgG whole serum  兔抗鸡IgG抗血清

hz-0314Rs Rabbit anti-chicken IgM whole serum  兔抗鸡IgM抗血清

hz-0303Rs Rabbit anti-Dog IgG whole serum  兔抗狗IgG抗血清

hz-0294Rs Rabbit anti-Goat IgG whole serum  兔抗羊IgG抗血清

hz-0370Rs Rabbit anti-Goat IgM whole serum  兔抗羊IgM抗血清

hz-0358Rs Rabbit anti-Guinea pig IgG whole serum  兔抗豚鼠IgG抗血清

hz-0375Rs Rabbit anti-Guinea pig IgM whole serum  兔抗豚鼠IgM抗血清

hz-0308Rs Rabbit anti-horse IgG whole serum  兔抗马IgG抗血清

hz-0297Rs Rabbit anti-human IgG whole serum  兔抗人IgG抗血清

hz-0345Rs Rabbit anti-human IgM whole serum  兔抗人IgM抗血清

hz-0364Rs Rabbit anti-human IgG F(ab')2 whole serum  兔抗人IgG F(ab')2抗血清

hz-0335Rs Rabbit anti-Monkey IgG whole serum  兔抗猴IgG抗血清

hz-0336Rs Rabbit anti-Monkey IgM whole serum  兔抗猴IgM抗血清

hz-0296Rs Rabbit anti-mouse IgG whole serum  兔抗小鼠IgG抗血清

hz-0368Rs Rabbit anti-mouse IgM whole serum  兔抗小鼠IgM抗血清

hz-0330Rs Rabbit anti-mouse Kappa Chain whole serum  兔抗小鼠k-链抗血清

hz-0377Rs Rabbit anti-mouse IgG-Fc fragment whole serum  兔抗小鼠IgG-Fc段抗血清

hz-0293Rs Rabbit anti-Rat IgG whole serum  兔抗大鼠IgG抗血清

hz-0346Rs Rabbit anti-Rat IgM whole serum  兔抗大鼠IgM抗血清

hz-0309Rs Rabbit anti-Pig IgG whole serum  兔抗猪IgG抗血清

hz-0403Rs Rabbit anti-MG IgG whole serum  兔抗长爪沙鼠IgG抗血清