获取电话英文名称 DYRK3
中文名称 双特异性酪氨酸磷酸化调节激酶3抗体
别 名 Dual specificity tyrosine phosphorylation-regulated kinase 3; hYAK3 2; Dual specificity tyrosine-phosphorylation-regulated kinase 3; Dyrk3; DYRK3_HUMAN; DYRK5; RED; REDK; Regulatory erythroid kinase.
说 明 书 0.1ml 0.2ml
研究领域 心血管 细胞生物 发育生物学 信号转导 干细胞 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 双特异性酪氨酸磷酸化调节激酶3抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DYRK3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
双特异性酪氨酸磷酸化调节激酶3抗体产品介绍 background:
Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene, which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation. Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases. Dyrk family members, including Dyrk1A (originally Dyrk), Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions. Two isoforms of human fetal brain Dyrk2 exist: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the amino terminus. Dyrk3 is strongly expressed in testis, only after the onset of spermatogenesis, and very weakly expressed in spleen and adrenal gland. The genes which encode Dyrk2 and Dyrk3 map to human chromosomes 12 and 1q32, respectively.
Function:
Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.
Subcellular Location:
Nucleus
Tissue Specificity:
Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus.
Post-translational modifications:
Autophosphorylated on tyrosine residues.
双特异性酪氨酸磷酸化调节激酶3抗体
hz-3546R RIP2 受体结合丝氨酸苏氨酸激酶2抗体
hz-3361R Phospho-RIP2 (Ser176) 磷酸化受体结合丝氨酸苏氨酸激酶2抗体
hz-3551R RIPK3 受体结合丝氨酸苏氨酸激酶3抗体
hz-3564R RICTOR 雷帕霉素靶蛋白复合体2抗体
hz-3387R Phospho-Rictor (Thr1135) 磷酸化雷帕霉素靶蛋白复合体2抗体
hz-2125R RNF126 环指蛋白126抗体
hz-2163R RNF148 环指蛋白148抗体
hz-6096R RNF139 环指蛋白139抗体
hz-4104R FXYD1 磷酸神经膜抗体
hz-1166R ROCK1 Rho相关蛋白激酶1抗体
hz-4630R phospho-ROCK1(Thr455/Ser456) 磷酸化Rho相关蛋白激酶1抗体
hz-1205R ROCK2 Rho相关蛋白激酶2抗体
hz-5674R phospho-ROCK2(Thr396) 磷酸化Rho相关蛋白激酶2抗体
hz-5675R phospho-ROCK2(Thr249) 磷酸化Rho相关蛋白激酶2抗体
hz-5676R phospho-ROCK2(Tyr256) 磷酸化Rho相关蛋白激酶2抗体
hz-1886R RPLP0 酸性核糖体磷蛋白大亚基P0抗体
hz-2504R ROS/c ros 活性氧簇ROS抗体
hz-3863R ROR Gamma/RORC/NR1F3 孤儿核受体抗体
hz-3565R RPS6 S6核糖体蛋白抗体
hz-3388R Phospho-S6 Ribosomal Protein (Ser235+Ser236) 磷酸化S6核糖体蛋白抗体
hz-3389R Phospho-S6 Ribosomal Protein (Ser240/244) 磷酸化S6核糖体蛋白抗体
hz-2777R Rb/P105 RB 成视网膜细胞瘤基因抗体
hz-1347R phospho-Rb/p105-Rb(Ser780) 磷酸化成视网膜细胞瘤抑癌蛋白抗体
hz-5348R phospho-FXYD1 (Ser83) 磷酸化磷酸神经膜抗体
hz-0278R RRAD RRAD抗体
hz-5349R phospho-FXYD1 (Ser88) 磷酸化磷酸神经膜抗体
hz-3554R Rsk2/MAPKAP Kinase 1b 核糖体S6激酶RSK2抗体
hz-3367R Phospho-RSK2 (Ser227) 磷酸化核糖体S6激酶RSK2抗体
hz-3368R Phospho-RSK2(Tyr529) 磷酸化核糖体S6激酶RSK2抗体
hz-3553R RSK3/Ribosomal S6 kinase 3 核糖体蛋白S6激酶家族RSK3抗体
