有丝分裂控制蛋白dis3抗体

英文名称    DIS3    

中文名称    有丝分裂控制蛋白dis3抗体    

别    名    Dis3; DIS3 mitotic control homolog (S. cerevisiae); dis3p; Exosome complex exonuclease RRP44; Mitotic control protein dis3 homolog; Protein DIS3 homolog; Ribosomal RNA processing protein 44; Ribosomal RNA-processing protein 44; RRP44; RRP44_HUMAN.    

说 明 书    0.2ml      

研究领域    细胞生物  细胞周期蛋白  细胞分化  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 有丝分裂控制蛋白dis3抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    105kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DIS3 (701-730aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

有丝分裂控制蛋白dis3抗体产品介绍    background:

Component of the exosome that has both 3'-5' exonuclease and endonuclease activities. Required for the 3'-processing of the 7S pre-RNA to the mature nuclear complex. As part of nucleoplasmic and probably cytoplasmic forms of the RNA exosome complex, it is involved in RNA processing and turnover. Also associated with the GTPase RAN.

Function:
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.

Subunit:
Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic-and nuclear-specific RNA exosome complex forms.

Subcellular Location:
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the RNR ribonuclease family.
Contains 1 PINc domain.    

有丝分裂控制蛋白dis3抗体

hz-5360R Phospho-Histone H2A.X (Tyr143)  磷酸化组蛋白H2AX抗体

hz-3652R Histone H2B  组蛋白H2B抗体

hz-3782R Acetyl-Histone H2B(K5)  乙酰化组蛋白H2B抗体

hz-3783R Acetyl-Histone H2B(K20)  乙酰化组蛋白H2B抗体

hz-2003R H1N1 Hhzagglutinin 2  甲型流感病毒血凝素抗体

hz-2004R H1N1 Hhzagglutinin 2  甲型流感病毒血凝素抗体

hz-4619R H1N1/H5N1/H3N2 nucleocapsid protein  A型流感病毒核衣壳蛋白抗体

hz-4620R H1N1/H5N1/H3N2 nucleocapsid protein  A型流感病毒核衣壳蛋白抗体

hz-4621R H1N1/H5N1/H3N2 nucleocapsid protein  A型流感病毒核衣壳蛋白抗体

hz-5888R Hyaluronidase2  透明质酸酶2/玻璃酸酶2抗体

hz-1235R Hyaluronidase-PH20/Haase  透明质酸酶/玻璃酸酶抗体

hz-3837R Hamartin/TSC1  结节性硬化症蛋白1抗体

hz-5600R phospho-TSC1(Ser505)  磷酸化结节性硬化症蛋白1抗体

hz-3653R SCHAD/HADHSC  短链L-3羟烷基辅酶A脱氢酶抗体

hz-3661R SCHAD/HADHSC(mouse, rat)  短链L-3羟烷基辅酶A脱氢酶抗体（小鼠，大鼠）

hz-5606R phospho-TSC1(Thr417)  磷酸化结节性硬化症蛋白1抗体

hz-5889R Hyaluronidase3  透明质酸酶2/玻璃酸酶2抗体

hz-2424R KCNH1/EAG1  钾离子通道蛋白EAG1抗体

hz-5123R Anterior Gradient 2  前梯度同源蛋白2抗体

hz-1815R HERG/KCNH2/ERG  特异性钾离子通道蛋白抗体

hz-2713R HAVCR1/TIM1  肾损伤分子1抗体（甲型肝炎病毒细胞受体1）

hz-0843R HA tag  HA tag标签抗体

hz-0966R HA tag  HA tag标签抗体

hzm-0966M HA tag(12CA5)  HA tag标签单克隆抗体

hz-0540R HAI-1  肝细胞生长因子激活物抑制剂抗体

hz-1557G HBsAg  人乙肝表面抗原抗体（包被）

hz-0847R HBA1/Alpha globin/Hhzoglobin  血红蛋白α1抗体

hzm-2118M hHb(H5A3)  人血红蛋白单克隆抗体

hzm-2024M HBsAg(H2F4)  人乙型肝炎表面抗原单克隆抗体（检测）

hzm-2000M HBcAg(1H8)  人乙型肝炎核心抗原单克隆抗体

hzm-2022M HBeAg(2E9)  人乙型肝炎e抗原单克隆抗体（1）

hzm-2023M HBeAg(2E6)  人乙型肝炎e抗原单克隆抗体（2）

hz-2169R VWCE  VWCE抗体