DNA断裂因子抗体（蛋白酶激活脱氧核糖核酸酶）

英文名称    DFFB    

中文名称    DNA断裂因子抗体（蛋白酶激活脱氧核糖核酸酶）    

别    名    CAD; Caldesmon; Caspase activated deoxyribonuclease; Caspase activated DNase; Caspase activated nuclease; CDM; CPAN; Deoxyribonuclease III, caspase activated; DFF 40; DFF2; DFF40; Didff; DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor subunit beta; DNA fragmentation factor, 40 Da, beta polypeptide (caspase activated DNase); DNA fragmentation factor, 40 kD beta subunit; DNA fragmentation factor, 40 kD, beta polypeptide; DNA fragmentation factor, 40kDa, beta polypeptide (caspase activated DNase); DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); DNAation factor, beta subunit; DFFB_HUMAN.    

说 明 书    0.2ml      

研究领域    细胞生物  细胞凋亡  细胞周期蛋白  激酶和磷酸酶  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 DNA断裂因子抗体（蛋白酶激活脱氧核糖核酸酶）（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    39kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DFFB    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

DNA断裂因子抗体（蛋白酶激活脱氧核糖核酸酶）产品介绍    background:

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008].

Function:
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. 

Subunit:
Heterodimer of DFFA and DFFB. Interacts with HIST1H1A. 

Subcellular Location:
Cytoplasm. Nucleus.

Similarity:
Contains 1 CIDE-N domain.     

DNA断裂因子抗体（蛋白酶激活脱氧核糖核酸酶）

hz-2135R FABPB  脑型脂肪酸结合蛋白抗体

hz-1040R factor V  凝血因子5抗体

hz-5914R CA III/Carbonic anhydrase 3  碳酸酐酶3抗体

hz-0332R factor VIII(FVIII) human  第八因子相关抗原抗体

hz-0434R factor VIII(FVIII)  第八因子相关抗原抗体

hz-5921R YBX-1/YB1  核酸敏感元件结合蛋白1

hz-1587R factor XIII  凝血因子13抗体(纤维蛋白稳定因子)

hz-0511R FADD  Fas死亡结构域相关蛋白

hz-5922R PGRMC  孕激素受体膜相关元件抗体

hz-1349R phospho-FADD(Ser194)  磷酸化Fas死亡结构域相关蛋白抗体

hz-5699R phospho-FADD(Ser194)  磷酸化Fas死亡结构域相关蛋白抗体

hz-5060R FADS1  脂肪酸去饱和酶1抗体

hz-1340R FAK/PTK2  粘着斑激酶抗体

hz-3159R Phospho-FAK/PTK2(Tyr397)  磷酸化粘着斑激酶抗体

hz-3160R Phospho-FAK(Tyr861)  磷酸化粘着斑激酶抗体

hz-3162R Phospho-FAK(Tyr576/577)  磷酸化粘着斑激酶抗体

hz-3163R Phospho-FAK(Tyr925)  磷酸化粘着斑激酶抗体

hz-3164R Phospho-FAK(Tyr407)  磷酸化粘着斑激酶抗体

hz-1639R phospho-FAK(Tyr577)  磷酸化粘着斑激酶抗体

hz-5539R phospho-FAK(Ser722)  磷酸化粘着斑激酶抗体

hz-5540R phospho-FAK(Tyr925)  磷酸化粘着斑激酶抗体

hz-1348R FAF1  Fas相关1因子抗体

hz-1642R phospho-FAK(Ser732)  磷酸化粘着斑激酶抗体

hz-3357R FAK2/PYK2  富含脯氨酸的酪氨酸激酶2抗体

hz-3400R phospho-Pyk2/PTK2B(Tyr402)  磷酸化富含脯氨酸的酪氨酸激酶2抗体

hz-3401R phospho-Pyk2 (Tyr881)  磷酸化富含脯氨酸的酪氨酸激酶2抗体

hz-5061R FAR2  脂肪酰辅酶A还原酶2抗体

hz-5541R phospho-PTK2(Tyr576+Tyr577)  磷酸化粘着斑激酶抗体

hz-2738R FANCD2  FANCD2抗体

hz-3015R phospho-FANCD2(Ser222)  磷酸化FANCD2抗体

hz-1580R FANCF  范可尼贫血相关蛋白F抗体

hz-0711R FAM3B/PANDER  胰腺衍生因子抗体

hz-5924R IMPDH2  5'肌苷磷酸脱氢酶2抗体

hz-0215R FAS/Apo-1/CD95  载脂蛋白A1抗体