细胞命运决定因子DACH1抗体

英文名称    DACH1    

中文名称    细胞命运决定因子DACH1抗体    

别    名    DACH; Dach1; DACH1_HUMAN; dachshund homolog 1 (Drosophila); Dachshund homolog 1; Dachsund homolog 1.    

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  免疫学  信号转导  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 细胞命运决定因子DACH1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    83kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DACH1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞命运决定因子DACH1抗体产品介绍    background:

DACH1 is similar to the Drosophila melanogaster dachshund gene, which encodes a nuclear factor essential for determining cell fates in the eye, leg, and nervous system of the fly. It is a member of the Ski gene family and is thought to be involved in eye development. Four alternatively spliced transcripts encoding different isoforms have been described for this gene. (from Entrez gene). DACH1 has also been found to inhibit oncogene-mediated breast tumor growth via downregulation of cyclin D1. Expression of DACH1 has been found to inversely correlate with metastasis. 

Function:
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Subunit:
Interacts with SIX1, SIX6 and EYA3. Interacts with NCOR1 and HDAC3 through its N-terminus. Interacts with SIN3A through its C-terminus. Interacts with SMAD3 and SMAD4.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.

Similarity:
Belongs to the DACH/dachshund family.

Database links:
 

UniProtKB/Swiss-Prot: Q9UI36.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

细胞命运决定因子DACH1抗体

hz-1954R BSEP/ABCB11  胆汁酸盐输出泵蛋白抗体

hz-2668R Bone sialoprotein  骨涎蛋白抗体

hz-0031R BTG2/TIS21  B细胞迁移基因2抗体

hz-2752R BTK/ATK  蛋白酪氨酸激酶ATK抗体

hz-3055R Phospho-Btk(Ser180)  磷酸化蛋白酪氨酸激酶ATK抗体

hz-3069R Phospho-BTK/BPK(Tyr223)  磷酸化蛋白酪氨酸激酶ATK抗体

hz-3820R BAP135/TFII I  蛋白酪氨酸激酶BAP135抗体

hz-4179R RAD9  细胞周期检查控制蛋白质抗体

hz-5642R phospho-RAD9(Ser272)  磷酸化细胞周期检查控制蛋白质抗体

hz-5643R phospho-RAD9(Ser277)  磷酸化细胞周期检查控制蛋白质抗体

hz-5654R phospho-RAD9(Ser328)  磷酸化细胞周期检查控制蛋白质抗体

hz-5655R phospho-RAD9(Ser336)  磷酸化细胞周期检查控制蛋白质抗体

hz-5656R phospho-RAD9(Ser375)  磷酸化细胞周期检查控制蛋白质抗体

hz-5657R phospho-RAD9(Ser380)  磷酸化细胞周期检查控制蛋白质抗体

hz-5658R phospho-RAD9(Ser387)  磷酸化细胞周期检查控制蛋白质抗体

hz-5659R phospho-RAD9(Tyr28)  磷酸化细胞周期检查控制蛋白质抗体

hz-5677R phospho-RAD51(Thr310)  磷酸化Rad51抗体

hz-5678R Phospho-RSK2(Ser369)  磷酸化核糖体S6激酶RSK2抗体

hz-0324R C5a  过敏毒素C5a（补体C5a）抗体

hz-2934R C3  过敏毒素C3（补体C3）抗体

hz-0367G human C3  补体C3抗体

hz-2673R C5b-9  末端补体复合物抗体

hz-3878R CQ028  多癌基因下调蛋白抗体

hz-0091R CA125/MUC16  卵巢癌抗原抗体

hz-1239R CA153/hzA/Mucin 1  乳腺癌相关抗原抗体

hz-1497R CA153/MUC1/KL-6  乳腺癌相关抗原抗体

hz-2776R CACH2/CaV1.2  L型钙通道蛋白抗体

hz-2781R CACNA1G/Cav3.1  电压依赖性钙通道Cav3.1抗体

hz-3930R CACNA1A/Cav2.1  电压依赖性钙通道Cav2.1抗体

hz-3932R CACH3/CaV1.3  L型钙通道蛋白a1亚型3抗体

hz-3933R CACH6/Cav2.3  L型钙通道蛋白a1亚型6抗体

hz-0043R DFF-40beta/CAD/CPAN  Caspase 激活的脱氧核糖核酸酶抗体

hz-0813R Casein  酪蛋白抗体

hz-0030M Calcineurin A/PP-2B alpha 1  钙调磷酸酶抗体