肿瘤细胞调亡素/死亡受体5抗体

英文名称    DR5    

中文名称    肿瘤细胞调亡素/死亡受体5抗体    

别    名    Death receptor 5; CD 262; CD262; CD262 antigen; Death domain containing receptor for TRAIL/Apo2L; Death receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; p53 regulated DNA damage inducible cell death receptor (killer); TNF related apoptosis inducing ligand receptor 2; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRANCER; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor superfamily member 10b; ZTNFR9.    

规格价格    0.1ml/600元 购买    0.2ml/1000元 购买        

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  细胞凋亡  细胞膜受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    48kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DR5 C-terminus    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

生 产 商    BIOSS    

PubMed    PubMed    

产品介绍    background:
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] 

Function:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.    

英文名称    DR5    

中文名称    肿瘤细胞调亡素/死亡受体5抗体    

别    名    Death receptor 5; CD 262; CD262; CD262 antigen; Death domain containing receptor for TRAIL/Apo2L; Death receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; p53 regulated DNA damage inducible cell death receptor (killer); TNF related apoptosis inducing ligand receptor 2; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRANCER; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor superfamily member 10b; ZTNFR9.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  细胞凋亡  细胞膜受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500肿瘤细胞调亡素/死亡受体5抗体 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    48kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human DR5 C-terminus    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

肿瘤细胞调亡素/死亡受体5抗体产品介绍    background:

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] 

Function:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.    

肿瘤细胞调亡素/死亡受体5抗体

hz-7534R PGC1 beta  过氧化物酶体增殖物激活受体γ辅激活子1β抗体

hz-7535R PGC1 alpha + beta  过氧化物酶体增殖物激活受体γ辅激活子1α+β抗体

hz-7536R SERPINA12/Vaspin  内脏脂肪组织源性丝氨酸蛋白酶抑制蛋白抗体

hz-7537R SIRT4/SIR 2 like protein 4  沉默调节相关蛋白4抗体

hz-7538R TRIB3/p65 interacting inhibitor of NF-kappaB  神经细胞死亡诱导蛋白激酶抗体

hz-7539R SERCA1 ATPase  肌浆/内质网钙ATP酶1抗体

hz-7540R GRK5  G蛋白偶联受体激酶5抗体

hz-7541R EDG3  内皮分化型G蛋白偶联受体3抗体

hz-7551R TNFAIP3 interacting protein 3/ABIN3  肿瘤坏死因子α诱导相互作用蛋白3抗体

hz-7542R RISC/Serine carboxypeptidase 1  丝氨酸羧肽酶1抗体

hz-2731R APS  APS抗体

hz-7544R SOAT1/ACAT1  胆固醇酰基转移酶1抗体

hz-3003R phospho-APS(Ser598)  磷酸化APS抗体

hz-7545R Scavenger Receptor BII  清道夫受体B2抗体

hz-7546R CD239  B细胞粘附分子CD239抗体

hz-3569R AP2 alpha  转录激活蛋白2α抗体

hz-7547R CPB2/Carboxypeptidase B2  胰羧肽酶B2抗体

hz-7548R Fibrinopeptide A  纤维蛋白肽A/血纤肽抗体

hz-7549R GAS 6  生长停滞特异性蛋白6抗体

hz-7550R AUP1/Ancient ubiquitous protein 1  原始广泛存在蛋白1抗体

hz-7552R Biglycan  骨/软骨蛋白多糖1抗体

hz-2532R ALT1  谷丙氨酸氨基转移酶1抗体

hz-7553R Eph receptor A2+A3+A4  内皮细胞受体蛋白酪氨酸激酶A2+A3+A4抗体

hz-7554R phospho-Eph receptor A2+A3+A4 (Tyr588 + Tyr596)  磷酸化内皮细胞受体蛋白酪氨酸激酶A2+A3+A4抗体

hz-7555R phospho-EPH A3+A4+A5 ( Tyr779)  磷酸化内皮细胞受体蛋白酪氨酸激酶A3+A4+A5抗体

hz-7556R FLAP/5-lipoxygenase activating protein  5脂氧合酶激活蛋白抗体

hz-7557R IKK alpha + IKK beta  KB抑制蛋白激酶α/β抗体

hz-7558R MC3 Receptor  黑素皮质素受体3抗体

hz-7559R PDGF AB+BB  血小板源性生长因子AB+BB抗体

hz-7560R CPLA2  胞浆型磷脂酶A2抗体

hz-7561R TIRAP  白细胞介素1受体衔接蛋白抗体

hz-7562R phospho-TIRAP(Tyr86)  磷酸化白细胞介素1受体衔接蛋白抗体

hz-7563R TNIP2/ABIN2/TNFAIP3 interacting protein 2  肿瘤坏死因子α诱导蛋白3相互作用蛋白2抗体

hz-7564R Azurocidin/Cationic antimicrobial protein 37  肝素结合蛋白/阳离子抗菌蛋白37/天青杀素抗体