获取电话英文名称 CPSF73
中文名称 剪切和多聚腺苷酸化特异性因子73蛋白抗体
别 名 Cleavage and polyadenylation specific factor 3 73kDa; Cleavage and polyadenylation specificity factor 73 kDa subunit; Cleavage and polyadenylation specificity factor subunit 3; CPSF 73; CPSF 73 kDa subunit; CPSF; CPSF-73; cpsf3; CPSF3_HUMAN; CPSF73; YSH1.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 结合蛋白 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 剪切和多聚腺苷酸化特异性因子73蛋白抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 77kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CPSF73
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
剪切和多聚腺苷酸化特异性因子73蛋白抗体产品介绍 background:
This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]
Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.
剪切和多聚腺苷酸化特异性因子73蛋白抗体
hz-3628R PRL3/PRL-R 磷酸酯酶3蛋白抗体
hz-2774R prox1 prox-1抗体
hz-1871R PH-4/P4H-TM 脯氨酸水解酶4抗体
hz-2311M Classical swine fever virus, CSFV 猪瘟病毒抗体
hz-2311R Classical swine fever virus 抗猪瘟病毒抗体
hz-0532R PHD3 脯氨酸羟化酶抗体
hz-3686R PHD2 脯氨酸羟化酶2抗体
hz-0024R presenilin 1/PS-1 (NT) 早老素蛋白-1抗体
hz-0025M presenilin 1/PS-1 (CT) 早老素蛋白-1抗体
hz-0024M presenilin 1/PS-1 早老素蛋白-1抗体
hz-3815R presenilin 2/PS-2 早老素蛋白-2抗体
hz-3866R Protor-1 乳腺癌抑制基因Protor1抗体
hz-5105R PRS3/PRE7 蛋白酶体复合物C5抗体
hzm-1625M PSA(Pa3) 人前列腺特异性抗原单克隆抗体(包被)
hzm-1626M PSA(PA5) 鼠抗人前列腺特异性抗原单克隆抗体(检测)
hzm-2465M CPSA(C2F9) 复合前列腺特异性抗原单克隆抗体
hz-2899R PMS/FOLH1/PMSA 前列腺特异膜抗原抗体
hz-1879R PSAP/PAP 前列腺酸性磷酸酶抗体
hz-2241R PSAP 鞘脂激活蛋白原抗体
hz-0669R PSCA 前列腺干细胞抗原抗体
hz-2395R Pescadillo 雌激素受体共调节因子抗体
hz-2341R PGF2 α 前列腺素F2a抗体
hz-3538R PSD93 突触后密度蛋白93抗体
hz-3348R Phospho-PSD93 (Tyr340) 磷酸化突触后密度蛋白93抗体
hz-0179R PSD95 突触后密度蛋白95抗体
hz-3349R Phospho-PSD95 (Tyr236/Tyr240) 磷酸化突触后密度蛋白95抗体
hz-2301R PSGL-1/CD162 P选择素糖蛋白配体1抗体
hz-1372R PSMD9 蛋白酶调解因子9抗体
hz-6087R PSMD10/Proteasome 26S S10 蛋白酶调解因子10抗体
hz-2787R LMP2 低分子质量蛋白2抗体
hz-2796R LMP7 低分子量蛋白酶体7抗体
hz-0561R P-selectin/CD62p P选择素抗体
hz-1036R L-Selectin/CD62L L选择素抗体
