磷酸化胞吞再循环相关衔接蛋白CENTB1抗体

英文名称    phospho-CENTB1 (Ser554)    

中文名称    磷酸化胞吞再循环相关衔接蛋白CENTB1抗体    

别    名    CENTB1 (phospho S554); p-CENTB1 (phospho S554); ACAP1 (phospho S554); p-ACAP1 (phospho S554); ACAP 1; ACAP1; ACAP1_HUMAN; ANK repeat and PH domain-containing protein 1; Arf GAP with coiled coil ANK repeat and PH domains 1; Arf GAP with coiled coil, ankyrin repeat, and pleckstrin homology domains 1; Arf-GAP with coiled-coil; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; CENT B1; Centaurin beta 1; Centaurin-beta-1; CENTB 1; Cnt b1; Cnt-b1; Cntb1; KIAA0050.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    细胞生物  信号转导      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 磷酸化胞吞再循环相关衔接蛋白CENTB1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    81kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthesised phosphopeptide derived from human CENTB1 around the phosphorylation site of Ser554    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化胞吞再循环相关衔接蛋白CENTB1抗体产品介绍    background:

ACAP1 is a member of the ADP ribosylation factor family of ARF6 GTPase-activating proteins (GAP). GAPs are important regulators of Arf function by controlling the return of ARF to its inactive state. ACAP1 is related to AGAP1 and ASAP1, and all three proteins are similarly expressed in fibroblast cells such as NIH/3T3. Internalization and recycling of integrin receptors is important in cell adhesion and migration modulation, and once inside a cell, proteins and membranes are transported to the endosome where they are sorted for recycling or degradation. ACAP1 promotes cargo sorting by associating directly to recycling cargo proteins. Preventing this interaction inhibits protein recycling. ACAP1 binds transferrin receptors, promoting their transport to the plasma membrane from the endosome. Akt induced phosphorylation of ACAP1 at Ser 554 regulates ACAP1 interaction to integrin in endosomes, and downregulation of Akt or ACAP1 may inhibit cell migration on Fibronectin.

Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.    

磷酸化胞吞再循环相关衔接蛋白CENTB1抗体

hz-1465P GRB2/ASH peptide  生长因子受体结合蛋白2抗原

hz-1351P GZMB/CCPI(Granzyme B)  颗粒酶B抗原

hz-1806P UTS2R/GPR14(Urotensin II receptor：G Protein Coupled Receptor 14)  G蛋白偶联受体14抗原

hz-1380P GPR30(G Protein Coupled Receptor 30)  G蛋白偶联受体30抗原

hz-1464P GnRHR peptide  促性腺激素释放激素受体抗原

hz-2501P KiSS-1R/GPR54/GPCR54(KiSS-1 receptor/G-Protein Coupled Receptor 54)  G蛋白偶联受体54抗原

hz-1209P GRK2/BARK1 (G-protein coupled receptor kinase 2)  G蛋白偶合受体激酶2抗原

hz-1161P GRM2/GLUR2 (Glutamate Receptor Metabotropic 2)  促代谢型谷氨酸受体2抗原

hz-0863P GRO Alpha/GRO/MGSA/CXCL1 protein (growthregulated oncogene Alpha)  生长调节致癌基因α/黑素瘤生长刺激因子α 抗原

hz-1219P GRP78(glucose regulated protein 78)  葡萄糖调节蛋白78抗原（热休克蛋白70蛋白5）

hz-2091P GSK-3 Alpha (Glycogen Synthase Kinase-3 alpha)  葡萄糖合成激酶-3α抗原(多肽抗原)

hz-2066P phospho-GSK-3 Beta(pSer9)  磷酸化葡萄糖合成激酶-3β抗原

hz-2073P phospho-GSK3 Alpha/ Beta(alpha + beta)(phospho Tyr279 + Tyr216)  磷酸化葡萄糖合成激酶3α/β抗原

hz-0837P GSR/GRase(glutathione reductase)  谷胱甘肽还原酶抗原

hz-1430P A/H1N1-M2 Human(Avian influenza Matrix Protein-2 Human)  A型人流感病毒H1N1-M2蛋白多肽

hz-0422P A/H1N1-M2 Swine(Avian influenza Matrix Protein-2 Swine)  A型猪流感病毒H1N1-M2蛋白

hz-2001P H1N1(Influenza A virus ,hhzagglutinin)  流感病毒A抗原

hz-2002P H1N1(Influenza A virus ,hhzagglutinin)  流感病毒A抗原

hz-2560P H2AX peptide  组蛋白H2AX多肽抗原

hz-2003P H1N1(Influenza A virus ,hhzagglutinin)  流感病毒A抗原

hz-2004P H1N1(Influenza A virus ,hhzagglutinin)  流感病毒A抗原

hz-1235P Haase(hyaluronidase)  透明质酸酶/玻璃酸酶抗原

hz-0843P HA tag  HA tag标签多肽

hz-0966P HA tag(map)  HA tag标签（分支多肽）

hz-0540P HAI-1(Hepatocyte Growth Factor Activator Inhibitor 1)  肝细胞生长因子激活物抑制因子抗原

hz-0847P HBA1(hhzoglobin alpha 1)  人类血红蛋白α1抗原

hz-2169P VWCE/URG11(von Willebrand factor C and EGF domain-containing)  乙型肝炎病毒X蛋白(HBxAg)抗原

hz-2171P URGCP/URG4(Up-regulator of cell proliferation)  乙型肝炎病毒X蛋白(HBxAg)抗原

hz-2172P URGCP/URG4(Up-regulator of cell proliferation)C terminal  肝炎病毒X蛋白(HBxAg)C端抗原

hz-0953P Beta-HCG (Human chorionic gonadotropin Beta)  人beta 亚基人绒毛膜促性腺激素抗原

hz-1912P Alpha-HCG(Human chorionic gonadotropin Alpha )  人α亚基人绒毛膜促性腺激素多肽抗原

hz-1745P HCFHrp/BTA(Bladdertumor antigen)human  膀胱肿瘤抗原

hz-1186P CD36L1/SRB1 peptide  高密度脂蛋白受体/清道夫受体抗原

hz-2155P HER2 receptor(NT)(erbB-2 isoform 2 receptor N-Terminus)  c-erbB-2受体抗体(N端)

hz-2156P HER2 receptor(NT)(erbB-2 isoform 2 receptor N-Terminus)  c-erbB-2受体抗原(N端)