阳离子通道精子相关蛋白β亚基抗体

英文名称    CATSPERB    

中文名称    阳离子通道精子相关蛋白β亚基抗体    

别    名    C14orf161; Cation channel sperm-associated protein subunit beta; Cation channel, sperm-associated, beta; Catsper channel auxiliary subunit beta; CatSper(beta); CATSPERB; FLJ14298; CTSRB_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  发育生物学  干细胞  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 阳离子通道精子相关蛋白β亚基抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    127kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CATSPERB    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

阳离子通道精子相关蛋白β亚基抗体产品介绍    background:

CatSpers are ion transport proteins located on the surface of sperm cells in the principal piece of the sperm tail. CatSpers are vital to sperm motility, fertilization and cAMP-mediated calcium influx in sperm. There are four CatSper proteins in mammalian sperm, namely CatSper (or CatSper1), CatSper2, CatSper3 and CatSper4. CatSper proteins are believed to assemble into a heterotetrameric complex, forming an alkalinization-activated Ca2+-selective channel. CatSper∫ is a multipass membrane protein that functions as an auxiliary protein of the CatSper channel. It contains a large extracellular domain and a number of N-glycosylation sites. CatSper∫ specifically interacts with CatSper1 and through this interaction plays an important role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization.

Function:
RelevanceCATSPERB is a component of a complex composed at least of CATSPER1, CATSPERB, CATSPERG and HSPA1B. CATSPERB contains at least 2 transmembrane domains and 8 N-glycosylation sites. CATSPERB is required for trafficking or formation of a stable channel complex. It is involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. There are 2 isoforms produced by alternative splicing.     

阳离子通道精子相关蛋白β亚基抗体

hz-3806R UCHL1/PGP9.5  神经细胞胞浆蛋白9.5抗体（蛋白基因产物9.5）

hz-1449R Prohibitin  抑制素/肿瘤抑制因子抗体

hz-0128R PI3K/PI3 kinase p85 alpha subunit  磷脂酰肌醇激酶抗体

hz-3332R phospho-PI3K p85(Tyr458)/p55(Tyr199)  磷酸化磷脂酰肌醇激酶抗体

hz-5538R phospho-PI3K p85/PIK3R1(Tyr368)  磷酸化磷脂酰肌醇激酶抗体

hz-5571R phospho-PIK3R1(Tyr467)  磷酸化磷脂酰肌醇激酶抗体

hz-2067R PIK3CA  磷脂酰肌醇激酶催化亚单位A抗体

hz-3593R PI3 Kinase p110 delta  磷脂酰肌醇激酶催化亚单位D抗体

hz-5572R phospho-PIK3R1(Tyr556)  磷酸化磷脂酰肌醇激酶抗体

hz-5570R phospho-PI3KCA(Tyr317)  磷酸化磷脂酰肌醇激酶催化亚单位A抗体

hz-5587R phospho-PI3K/PIK3CD(Tyr524)  磷酸化磷脂酰肌醇激酶催化亚单位D抗体

hz-0420R PIBF  孕激素诱导阻断因子抗体

hz-4670R PILR beta  细胞表面受体PILRβ抗体

hz-2690R PILR beta  细胞表面受体PILRβ抗体

hz-3540R PIM1  丝氨酸/苏氨酸激酶蛋白Pim1抗体

hz-3353R Phospho-PIM1(Tyr218)  磷酸化前病毒整合位点蛋白1抗体

hz-1872R PIRH2  泛素连接酶抗体

hz-3541R Pin1  肽基脯氨酞顺反异构酶Pinl抗体

hz-3354R Phospho-Pin1 (Ser16)  磷酸化肽基脯氨酞顺反异构酶Pinl抗体

hz-4160R PI 3 Kinase p85 beta  磷脂酰肌醇激酶p85β抗体

hz-5582R phospho-PIK3R2(Tyr467)  磷酸化磷脂酰肌醇激酶p85β抗体

hz-0665R PIWIL1/Miwi  piwi样1蛋白抗体

hz-3817R Piwil2/Mili  piwi样2蛋白抗体

hz-5001R PCK1  磷酸烯醇丙酮酸羧激酶抗体

hz-5002R PCK2  磷酸羧化酶2抗体

hz-0520R PKA/PKAcat/PKACB  蛋白激酶A抗体

hz-3725R Phospho-PRKACB(Thr198)  磷酸化蛋白激酶C亚性抗体

hz-2371R PKA C alpha+beta  蛋白激酶C抗体

hz-4024R phospho-PKA beta(Ser338)  磷酸化蛋白激酶Aβ抗体

hz-3964R PKA gamma  蛋白激酶Aγ抗体

hz-3963R PKA R2/PKA IIα  蛋白激酶A受体2α亚基抗体

hz-4022R phospho-PKA R2 (Ser96)  磷酸化蛋白激酶A受体2α亚基抗体

hz-3965R PKA regulatory subunit I beta  蛋白激酶受体相关1β抗体

hz-0115M PKB/AKT-1  蛋白激酶B

hz-3969R PRKAR1  蛋白激酶A调节亚基a1抗体

hz-3643R PLASTIN3/T Plastin  丝束蛋白T Plastin抗体

hz-3807R PLAP/Phospholipase A2 activator protein  磷脂酶A2激活蛋白抗体

hz-3534R PLC beta 3  磷酯酶Cβ3抗体

hz-3340R Phospho-PLC beta3 (Ser537)  磷酸化磷酯酶Cβ3抗体