获取电话英文名称 C1orf77
中文名称 1号染色体开放阅读框77抗体
别 名 Chromatin target of PRMT1 protein; Chromosome 1 open reading frame 77; CHTOP; CHTOP_HUMAN; DKFZp547E1010; FOP; Friend of PRMT1 protein; MGC131924; MGC86949; OTTHUMP00000035122; OTTHUMP00000035123; Pp7704; RP1 178F15.2; Small arginine- and glycine-rich protein; Small protein rich in arginine and glycine; SRAG.
说 明 书 0.2ml
研究领域 细胞生物 免疫学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 1号染色体开放阅读框77抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human C1orf77
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:1号染色体开放阅读框77抗体
C1orf77, also known as Friend of PRMT1 protein, is a 248 amino acid protein that plays an essential role in the ligand-dependent activation of estrogen receptor target genes. C1orf77 is tightly associated with chromatin and is modified by both asymmetric and symmetric arginine methylation. Depletion of C1orf77 results in almost complete block of estradiol-induced promter occupancy by the estrogen receptor. Also, complete knockdown of C1orf77 mRNA in adult erythroid progenitors stongly induces fetal hemoglobin, suggesting that C1orf77 is a critical modulator of γ-globin gene expression. There are two isoforms of C1orf77 that are produced as a result of alternative splicing events. The gene encoding C1orf77 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1.
Function:
Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
1号染色体开放阅读框77抗体
hz-0327P-APhz Bovine IgM/APC 荧光素APC标记牛IgM
hz-0310P-APhz Chicken IgG/APC 荧光素APC标记鸡IgG
hz-0314P-APhz Chicken IgM/APC 荧光素APC标记鸡IgM
hz-0303P-APhz dog IgG/APC 荧光素APC标记狗IgG
hz-0373P-APhz dog IgM/APC 荧光素APC标记狗IgM
hz-0370P-APhz Goat IgM/APC 荧光素APC标记羊IgM
hz-0358P-APhz Guinea IgG/APC 荧光素APC标记豚鼠IgG
hz-0375P-APhz Guinea IgM/APC 荧光素APC标记豚鼠IgM
hz-0308P-APhz Horse IgG/APC 荧光素APC标记马IgG
hz-0374P-APhz Horse IgM/APC 荧光素APC标记马IgM
hz-0297P-APhz human IgG/APC 荧光素APC标记人IgG
hz-0345P-APhz human IgM/APC 荧光素APC标记人IgM
hz-0360P-APhz human IgA/APC 荧光素APC标记人IgA
hz-0335P-APhz Monkey IgG/APC 荧光素APC标记猴IgG
hz-0336P-APhz Monkey IgM/APC 荧光素APC标记猴IgM
hz-0368P-APhz Mouse IgM/APC 荧光素APC标记小鼠IgM
hz-0309P-APhz pig IgG/APC 荧光素APC标记猪IgG
hz-0369P-APhz Rabbit IgM/APC 荧光素APC标记兔IgM
hz-0346P-APhz Rat IgM/APC 荧光素APC标记大鼠IgM
hz-0789P-APhz Insulin Protein /APC 荧光素APC标记猪胰岛素蛋白
hz-P0002-APhz KLH/APC 荧光素APC标记血蓝蛋白
hz-P0003-APhz OVA/APC 荧光素APC标记鸡卵白蛋白
hz-0945P-APhz HSA(Human sermu albumin)/APC 荧光素APC标记人血白蛋白
hz-2179P-APhz AACT/APC 荧光素APC标记胰糜蛋白酶
hz-0437P-hzy3 Streptavidin/Cy3 荧光素Cy3标记链霉亲和素
hz-0312P-hzy3 Avidin/Cy3 荧光素Cy3标记亲合素
hz-0362P-hzy3 Protein A/Cy3 Cy3标记蛋白A
hz-0295P-hzy3 Rabbit IgG/Cy3 荧光素Cy3标记兔IgG(细胞流式同型对照)
hz-0296P-hzy3 Mouse IgG/Cy3 荧光素Cy3标记小鼠IgG(细胞流式同型对照)
hz-0294P-hzy3 Goat IgG/Cy3 荧光素Cy3标记羊IgG(细胞流式同型对照)
hz-0293P-hzy3 Rat IgG/Cy3 荧光素Cy3标记大鼠IgG(细胞流式同型对照)
hz-0326P-hzy3 Bovine IgG/Cy3 荧光素Cy3标记牛IgG
hz-0327P-hzy3 Bovine IgM/Cy3 荧光素Cy3标记牛IgM
hz-0310P-hzy3 Chicken IgG/Cy3 荧光素Cy3标记鸡IgG
hz-0314P-hzy3 Chicken IgM/Cy3 荧光素Cy3标记鸡IgM
hz-0303P-hzy3 dog IgG/Cy3 荧光素Cy3标记狗IgG
hz-0373P-hzy3 dog IgM/Cy3 荧光素Cy3标记狗IgM
hz-0370P-hzy3 Goat IgM/Cy3 荧光素Cy3标记羊IgM
hz-0358P-hzy3 Guinea pig IgG/Cy3 荧光素Cy3标记豚鼠IgG
