磷酸化淋巴细胞衍生C-型凝集素抗体

英文名称    phospho-C-REL (Ser503)    

中文名称    磷酸化淋巴细胞衍生C-型凝集素抗体    

别    名    c-Rel (phospho S503); c-Rel (phospho Ser503); p-c-Rel (phospho S503); p-c-Rel (S503); Avian reticuloendotheliosis; C REL; C Rel protein; c Rel proto oncogene protein; Oncogene REL; Oncogene REL avian reticuloendotheliosis; REL; v rel avian reticuloendotheliosis viral oncogene homolog; v rel reticuloendotheliosis viral oncogene homolog.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  信号转导  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 磷酸化淋巴细胞衍生C-型凝集素抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    69kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthesised phosphopeptide derived from human C-REL around the phosphorylation site of Ser503    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化淋巴细胞衍生C-型凝集素抗体产品介绍    background:

The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM, May 2008]. 

Function:
Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.    

磷酸化淋巴细胞衍生C-型凝集素抗体

hz-3867R RGS19  G蛋白信号转导调节因子19抗体

hz-5686R phospho-RGS19(Ser22)  磷酸化G蛋白信号转导调节因子19抗体

hz-5687R phospho-RGS19(Ser24)  磷酸化G蛋白信号转导调节因子19抗体

hz-5688R phospho-RGS19(Ser151)  磷酸化G蛋白信号转导调节因子19抗体

hz-5689R phospho-RGS19(Tyr143)  磷酸化G蛋白信号转导调节因子19抗体

hz-1180R RhoA  RhoA抗体

hz-1480R Rho C  RhoC抗体

hz-5949R RNF56/CBLB  环指蛋白56

hz-3546R RIP2  受体结合丝氨酸苏氨酸激酶2抗体

hz-3361R Phospho-RIP2 (Ser176)  磷酸化受体结合丝氨酸苏氨酸激酶2抗体

hz-3551R RIPK3  受体结合丝氨酸苏氨酸激酶3抗体

hz-3564R RICTOR  雷帕霉素靶蛋白复合体2抗体

hz-3387R Phospho-Rictor (Thr1135)  磷酸化雷帕霉素靶蛋白复合体2抗体

hz-2125R RNF126  环指蛋白126抗体

hz-2163R RNF148  环指蛋白148抗体

hz-6096R RNF139  环指蛋白139抗体

hz-4104R FXYD1  磷酸神经膜抗体

hz-1166R ROCK1  Rho相关蛋白激酶1抗体

hz-4630R phospho-ROCK1(Thr455/Ser456)  磷酸化Rho相关蛋白激酶1抗体

hz-1205R ROCK2  Rho相关蛋白激酶2抗体

hz-5674R phospho-ROCK2(Thr396)  磷酸化Rho相关蛋白激酶2抗体

hz-5675R phospho-ROCK2(Thr249)  磷酸化Rho相关蛋白激酶2抗体

hz-5676R phospho-ROCK2(Tyr256)  磷酸化Rho相关蛋白激酶2抗体

hz-1886R RPLP0  酸性核糖体磷蛋白大亚基P0抗体

hz-2504R ROS/c ros  活性氧簇ROS抗体

hz-3863R ROR Gamma/RORC/NR1F3  孤儿核受体抗体

hz-3565R RPS6  S6核糖体蛋白抗体

hz-3388R Phospho-S6 Ribosomal Protein (Ser235+Ser236)  磷酸化S6核糖体蛋白抗体

hz-3389R Phospho-S6 Ribosomal Protein (Ser240/244)  磷酸化S6核糖体蛋白抗体

hz-2777R Rb/P105 RB  成视网膜细胞瘤基因抗体

hz-1347R phospho-Rb/p105-Rb(Ser780)  磷酸化成视网膜细胞瘤抑癌蛋白抗体

hz-5348R phospho-FXYD1 (Ser83)  磷酸化磷酸神经膜抗体

hz-0278R RRAD  RRAD抗体

hz-5349R phospho-FXYD1 (Ser88)  磷酸化磷酸神经膜抗体