老年痴呆相关类钙粘蛋白CS1抗体

英文名称    CLSTN1    

中文名称    老年痴呆相关类钙粘蛋白CS1抗体    

别    名    Calsyntenin 1; Alc alpha; Alc-alpha; Alcadein alpha 1; Alcadein alpha; Alcadein-alpha; alcalpha1; alcalpha2; Alzheimer related cadherin like protein; Alzheimer-related cadherin-like protein; Calsyntenin-1; Calsyntenin1; CLSTN 1; Clstn1; CS1; CSTN1; CSTN1_HUMAN; CTF1-alpha; FLJ32258; KIAA0911; Non classical cadherin XB31alpha; Non-classical cadherin XB31alpha; PIK3CD; SAlc-alpha; XB31alpha.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  神经生物学  信号转导  Alzheimer's      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 老年痴呆相关类钙粘蛋白CS1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    89/107kDa    

细胞定位    细胞核 细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Calsyntenin 1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

老年痴呆相关类钙粘蛋白CS1抗体产品介绍    background:

Members of the calsyntenin protein family are localized to the post-synaptic membrane of exicitatory central nervous system (CNS) synapses. Calsyntenin-1, also known as CSTN1, PIK3CD, Alzheimer-related cadherin-like protein, non-classical cadherin XB31alpha, KIAA0911, ALC-ALPHA, alcalpha1, alcalpha2 or FLJ32258, is a 981 amino acid single-pass type I membrane protein that localizes to the membrane of endoplasmic reticulum, Golgi apparatus, cell projections and postsynaptic cells. Expressed in brain, calsyntenin-1 is also found at lower levels in placenta, skeletal muscle, heart and kidney. Calsyntenin-1 binds synaptic Ca2+ with its cytoplasmic domain and plays a role in extracellular proteolysis. Calsyntenin-1 is also known to form a complex with X11 Beta and APP to suppress the metabolic cleavage of APP, and docks vesicular cargo to KLC1. Calsyntenin-1 may be related to the development or progression of Alzheimer’s disease, and two calsyntenin-1 isoforms are produced as a result of alternative splicing events.

Function:
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.    

老年痴呆相关类钙粘蛋白CS1抗体

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hz-0799R CTn1/Troponin I/TNNC1  心肌肌钙蛋白抗体

hz-2534R CT-1/CTF1  心肌营养素1抗体

hz-1592R CA I/Carbonic anhydrase 1  碳酸酐酶1抗体

hz-1685R CTNNAL1  粘附分子相关蛋白a1抗体

hz-1709R CA II/Carbonic anhydrase 2  碳酸酐酶2抗体

hz-4029R CA IX  碳酸酐酶9抗体

hz-1078R CAS/CSE1  细胞凋亡敏感性基因抗体

hz-3496R Phospho-Cas (Tyr165)  磷酸化细胞凋亡敏感性基因

hz-0169R Caspase-1(actived P10)  天冬氨酸-胱氨酸特异性蛋白酶家族抗体

hz-5802R Caspase 2  半胱胺酸蛋白酶-2抗体

hz-0092R Caspase-10  半胱胺酸蛋白酶-10抗体

hz-1105R Caspase-12  半胱胺酸蛋白酶蛋白-12抗体

hz-0967R Caspase-12  半胱胺酸蛋白酶蛋白-12抗体

hz-0053R Caspase-13/4  半胱胺酸蛋白酶蛋白-13抗体

hz-0081R Caspase-3(Active)  活化半胱胺酸蛋白酶蛋白-3抗体

hz-0087R caspase-3 p12 subunit  活化半胱胺酸蛋白酶蛋白-3抗体

hz-2593R caspase-3 p11  半胱天冬酶-3酶原抗体

hz-0082R Caspase 4  半胱胺酸蛋白酶蛋白-4抗体

hz-0151R Caspase-6 (CT)  半胱胺酸蛋白酶蛋白-6抗体（C端）

hz-0084R Caspase-6 (NT)  半胱胺酸蛋白酶蛋白-6抗体(N端)

hz-0084M Caspase-6 (NT)  半胱胺酸蛋白酶蛋白-6抗体(N端)

hz-5240R phospho-Caspase 6 (Ser257)  磷酸化半胱胺酸蛋白酶蛋白6抗体

hz-3665R Caspase-7  半胱胺酸蛋白酶蛋白-7抗体

hz-2322R Caspase-7  半胱胺酸蛋白酶蛋白-7抗体

hz-0052R Caspase 8  半胱氨酸蛋白酶8抗体

hz-0049R Caspase-9  白介素1-β转化酶样凋亡蛋白酶6抗体

hz-0050R Caspase-9  白介素1-β转化酶样凋亡蛋白酶6抗体

hz-3082R Phospho-Caspase-9 (Thr125)  磷酸化半胱氨酸蛋白酶9抗体

hz-3083R Phospho-Caspase-9 (Tyr153)  磷酸化半胱氨酸蛋白酶9抗体