信号转导蛋白亚基6抗体

英文名称    COPS6    

中文名称    信号转导蛋白亚基6抗体    

别    名    JAB1 containing signalosome subunit 6; COP9 subunit 6 (MOV34 homolog, 34 kD); MOV34 homolog, 34 kD; COP9 (constitutive photomorphogenic), subunit 6; COP9 complex S6; COP9 signalosome complex subunit 6; COP9 signalosome subunit 6; cops6; CSN6; CSN6_HUMAN; hVIP; JAB1-containing signalosome subunit 6; MOV34 homolog; MOV34-34KD; Sgn3; SGN6; Signalosome subunit 6; VIP/MOV34; Vpr interacting protein; Vpr-interacting protein.    

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  信号转导  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）信号转导蛋白亚基6抗体 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    36kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human COPS6    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

信号转导蛋白亚基6抗体产品介绍    background:

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets.     

信号转导蛋白亚基6抗体

hz-7885R CCNDBP1/GCIP  周期素D结合蛋白1抗体

hz-7886R AFF4  淋巴细胞相关AF4样蛋白抗体

hz-7887R Cyclin K/CCNK  周期素K抗体

hz-7888R Cyclin L/CCNL1  周期素L抗体

hz-7889R CCNYL1  周期素样Y1抗体

hz-7890R Cyclin J  周期素J抗体

hz-7891R Cyclin T2  周期素T2抗体

hz-7892R AIMP3/p18  抑癌蛋白AIMP3抗体

hz-7893R CABLES1  细胞周期蛋白依赖性激酶CABLES1抗体

hz-7894R CDCA3  细胞分裂周期相关蛋白3抗体

hz-7895R DBF4A  S期激酶活化蛋白DBF4A抗体

hz-3765R SAP/Serum Amyloid P  血清淀粉样蛋白P成份抗体

hz-7896R MNAT1  细胞周期G1的相互作用蛋白抗体

hz-7897R CDC2L5  细胞分裂周期2样蛋白激酶5抗体

hz-7898R PICK1  蛋白激酶Cα相互作用蛋白1抗体

hz-7899R INCA1  INCA1蛋白抗体

hz-7900R MS4A3/CD20L  CD20样蛋白抗体（造血干细胞4跨膜蛋白3）

hz-0057R Amylin  糖尿病相关肽/胰岛淀粉样肽抗体

hz-7901R SPDYA  细胞周期G2/M期快速诱导蛋白SPDYA抗体

hz-7902R phospho-FRS2(Tyr436)  磷酸化成纤维细胞生长因子受体底物2抗体

hz-7903R ASP/AKAP associated Sperm Protein  精子相关蛋白AKAP抗体

hz-7904R AKAP6  蛋白激酶A锚定蛋白6抗体

hz-7905R BRSK1  丝氨酸/苏氨酸蛋白激酶SAD-B抗体

hz-7906R CERK  神经酰胺激酶CERK抗体

hz-7907R CLK2  细胞分裂周期样激酶2抗体

hz-7908R CLK3  细胞分裂周期样激酶3抗体

hz-7909R phospho-CK II beta(Ser209)  磷酸化丝氨酸/苏氨酸蛋白激酶II β(casein kinase IIβ)抗体

hz-7910R DUSP26/MKP8  双特异性蛋白磷酸酶26抗体（丝裂原活化蛋白激酶磷酸酶8）

hz-7911R phospho-FER/TYK3(Tyr402)  磷酸化酪氨酸蛋白激酶3抗体

hz-7912R GAK protein  细胞周期蛋白G相关激酶抗体

hz-7913R phospho-LATS1+LATS2 (Thr1079 +Thr1041)  磷酸化肿瘤抑制基因LATS1/LATS2抗体

hz-7914R MOBKL2B  Mob1同源蛋白MOBKL2B抗体

hz-7915R MOBKL2C  Mob1同源蛋白MOBKL2C抗体

hz-7916R N acetylglucosamine kinase  N-乙酰氨基葡萄糖激酶抗体

hz-7917R NUCKS1  核酪蛋白激酶和细胞周期蛋白依赖性激酶底物1抗体