获取电话英文名称 CIP2A
中文名称 蛋白磷酸酶PP2A癌抑制蛋白抗体
别 名 p90 Autoantigen Cancerous Inhibitor of Protein Phosphatase 2A; CIP2A; FLJ12850; KIAA1524; MGC163436; p90; CIP2A/p90 Autoantigen.
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 免疫学 肿瘤细胞生物标志物
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 蛋白磷酸酶PP2A癌抑制蛋白抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human p90 Autoantigen
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
蛋白磷酸酶PP2A癌抑制蛋白抗体产品介绍 background:
Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A, p90 Autoantigen), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, p90 Autoantigen promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of p90 Autoantigen is demonstrated by transformation of human cells by overexpression of p90 Autoantigen. Importantly, p90 Autoantigen is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
Subunit:
Interacts with MYC.
蛋白磷酸酶PP2A癌抑制蛋白抗体
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hz-6614R BMP5 骨形态发生蛋白5抗体
hz-6615R Hepatic lipase 肝脂酶抗体
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hz-6620R CRHR2 促肾上腺皮质释放激素受体2抗体
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hz-6622R Glycophorin C/CD236 糖蛋白C抗体
hz-6623R Frizzled 2 Wnt信号受体FZD2蛋白抗体
hz-6624R IHH HHG2抗体
hz-6625R Insig2 胰岛素诱导基因2抗体
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hz-6631R Neurotensin/NTS 神经紧张素抗体
