获取电话英文名称 CD168
中文名称 透明质酸介导细胞游走受体抗体
别 名 CD168; CD168 antigen; HMMR; HMMR_HUMAN; Hyaluronan mediated motility receptor; Hyaluronan-mediated motility receptor (RHAMM); IHABP; Intracellular hyaluronic acid-binding protein; Intracellular hyaluronic acid-binding protein; MGC119494; MGC119495; Receptor for hyaluronan-mediated motility; RHAMM; Hyaluronan mediated motility receptor
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 免疫学 染色质和核信号 细胞膜受体 细胞表面分子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 透明质酸介导细胞游走受体抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82-84kDa
细胞定位 细胞浆 细胞膜 细胞外基质
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RHAMM C-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
透明质酸介导细胞游走受体抗体产品介绍 background:
The CD168 antigen is a non-integral cell surface hyaluronan receptor and intracellular protein. When hyaluronan binds to CD168, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. CD168 activation regulates various cellular processes including cell migration, proliferation, signaling, regulation of gene expression, cell differentiation, morphogenesis, and metastasis via both extracellular and intracellular pathways. CD168 is involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. CD168 is also a subunit of the HARC complex. CD168 knockdown in human embryonic stem cells results in downregulation of several pluripotency markers, induction of early extraembryonic lineages, loss of cell viability, and changes in cell cycle.
Function:
Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.
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