磷酸化细胞凋亡敏感性基因

英文名称    Exportin-2 (Tyr165)    

中文名称    磷酸化细胞凋亡敏感性基因    

别    名    Cellular Apoptosis Susceptibility; exportin-2; CAS; Cellular apoptosis susceptibility protein; Chromosome segregation 1 (yeast homolog) like; Chromosome segregation 1 Like; Chromosome segregation 1 like protein; Chromosome segregation gene CSE1; CSE 1; CSE 1 chromosome segregation 1 like; CSE 1 chromosome segregation 1 like protein; CSE 1L; CSE1; CSE1 chromosome segregation 1 like; CSE1 chromosome segregation 1 like protein; CSE1L; Exp 2; Exp2; Exportin 2; Exportin2; Exportin-2; Importin alpha re exporter; XPO2_HUMAN; Chromosome segregation 1-like protein; Importin-alphare-exporter.    

说 明 书    

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  免疫学  信号转导  细胞凋亡  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 磷酸化细胞凋亡敏感性基因（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    107kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human Cas around the phosphorylation site of Tyr165    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化细胞凋亡敏感性基因产品介绍    background:

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].

Function:
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.    

磷酸化细胞凋亡敏感性基因

hz-6092R RHOBTB1  Rho相关结构域BTB蛋白质1抗体

hz-6093R RIL  抑癌基因PDLIM4抗体

hz-6094R RIN1  RAS抑制蛋白1抗体

hz-6095R RND3/RHOE  Rho家族GTP酶3抗体

hz-6097R RSRC2  食道癌抑制生长蛋白抗体

hz-6098R PARG1/Rho GTPase activating protein 29  Rho GTP酶激活蛋白29抗体

hz-6099R SASH1  肿瘤抑制基因PEPE1抗体

hz-6100R SESN3  Sestrin3抗体

hz-5154R LSP1  白细胞F肌动蛋白结合蛋白抗体

hz-1016R E-cadherin/CD324  上皮钙粘附分子抗体

hz-6101R RUNX1T1/ETO  周期素D相关蛋白抗体

hz-4213R LARG  Rho的鸟嘌呤核苷酸交换因子12抗体

hz-6102R SCHIP1/IQCJ  IQCJ抗体

hz-6103R SEZ6L  癫痫样相关蛋白6抗体

hz-6104R SHPRH  组蛋白连接作用蛋白抗体

hz-6105R SIRT3  线粒体乙酰化酶3抗体

hz-6106R SLC5A8  钠碘转运体蛋白8抗体

hz-6107R HLTF  解旋酶样转录因子抗体

hz-6109R SNF5  转录调控激活蛋白SNF5抗体

hz-6110R SPARCL1/Ecm2  细胞外基质蛋白2抗体

hz-6111R SSBP2  抑癌基因SSDP2抗体

hz-6112R ST5/DENND2B  抑癌蛋白5抗体

hz-6113R TCHP  抑癌蛋白TCHP抗体

hz-6114R TUSC1  肺癌抑癌蛋白1抗体

hz-6115R TUSC3  前列腺癌抑癌蛋白3抗体

hz-6116R TUSC5  抑癌基因5抗体

hz-6117R Tomoregulin-1  脑肿瘤抑癌蛋白1抗体

hz-6118R VILIP1  神经视锥蛋白样1抗体(神经钙蛋白)

hz-6119R ZNF185  锌指蛋白185抗体

hz-6121R RBMX  糖蛋白P43抗体

hz-6123R PRB2/p130  视网膜母细胞瘤相关蛋白p130抗体