淋巴细胞衍生C-型凝集素抗体

英文名称    C-REL    

中文名称    淋巴细胞衍生C-型凝集素抗体    

别    名    Avian reticuloendotheliosis; C REL; C Rel protein; c Rel proto oncogene protein; Oncogene REL; Oncogene REL avian reticuloendotheliosis; REL; v rel avian reticuloendotheliosis viral oncogene homolog; v rel reticuloendotheliosis viral oncogene homolog; Proto-oncogene c-Rel; REL_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  信号转导  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Pig, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 淋巴细胞衍生C-型凝集素抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    68kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human C-REL    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

淋巴细胞衍生C-型凝集素抗体产品介绍    background:

The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM, May 2008].

Function:
Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.    

淋巴细胞衍生C-型凝集素抗体

hz-0887P Measles virus protein(Plant2 derived measles virus hhzagglutinin protein)  麻疹病毒红血球凝集素蛋白多肽

hz-0888P Measles virus protein(Plant2 derived measles virus hhzagglutinin protein)  麻疹病毒红血球凝集素蛋白多肽

hz-0664P HMGB1 (High Mobility Group Box protein 1)  高迁移率族蛋白-1(抗原)

hz-0455P HSL(hormone-sensitive lipase)  荷尔蒙敏感脂肪酸（抗原）

hz-0730P HSP-27(Heat Shock Protein 27)  热休克蛋白-27(抗原)

hz-0696P HSP-90Alpha(Heat Shock Protein 90Alpha )  热休克蛋白90α(抗原)

hz-0135P HSP-90 Beta (heat sock protein-90 Beta)  热休克蛋白-90β （抗原）

hz-0284P IASPP(inhibitory mhzber of the ASPP family)  肿瘤细胞凋亡ASPP家族的另一个成员(抗原)

hz-0608P CD54/ICAM-1  细胞间粘附分子-1

hz-0812P IL-1 Beta(Interleukin-1 Beta)  白介素1β（白细胞介素-1β）(多肽抗原)

hz-0445P IL1RAPL1 (Interleukin 1 receptor accessory protein-like 1)  白介素受体相关蛋白样1前体蛋白（抗原）

hz-0379P IL-6(Interleukin-6)  白介素6（白细胞介素-6）(多肽抗原)

hz-0698P IL-10(Interleukin-10)  白介素10（白细胞介素-10）(抗原)

hz-0780P IL-8  白介素8（白细胞介素-8）(抗原)

hz-0681P Insulin Receptor(ISR)  胰岛素受体（抗原）

hz-0641P Integrin Alpha 4/ITGA4(Integrin alpha 4)  整合素-α（抗原）

hz-0705P LDL-R(Low-density lipoprotein receptor precursor)  低密度脂蛋白受体(抗原)

hz-0722P Ki-67 peptides  Ki-67 Antigen(多肽抗原)

hz-0749P Kiss-1(Metastasis-suppressor KiSS-1 precursor)  肿瘤转移抑制基因（抗原)

hz-0864P 重组K3蛋白  重组K3蛋白

hz-2143P Snake poison Protein  蛇毒蛋白

hz-2144P Snake poison Protein  蛇毒蛋白

hz-0910P Batroxobin Protein  蛇毒巴曲酶全蛋白

hz-0409P Leptin  瘦素（抗原)

hz-0410P Leptin receptor  瘦素受体（抗原）

hz-0759P Lpin1 protein  Lpin1 protein(抗原)

hz-0484P Lumbrokinase  蚯蚓纤溶酶(蚓激酶抗原)

hz-0738P Livin (Inhibitors of apoptosis proterins Livin)  一种新的凋亡抑制蛋白(抗原)

hz-0637P p38 MAPK/MKK3/MAPKK14  丝裂原活化蛋白激酶p38(抗原)

hz-0401P Metal ion transporter  拟南介金属离子转运蛋白(抗原)