获取电话英文名称 Cyclin H
中文名称 周期素H抗体
别 名 6330408H09Rik; AI661354; AV102684; AW538719; CAK; CAK complex subunit; ccnh; CCNH_HUMAN; CDK activating kinase; CDK activating kinase complex subunit; Cyclin dependent kinase activating kinase; cyclin dependent kinase activating kinase complex subunit; Cyclin H; Cyclin-H; CyclinH; MO15 associated protein; MO15-associated protein; p34; p36; p37.
说 明 书 0.2ml
研究领域 细胞生物 染色质和核信号 细胞周期蛋白 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 周期素H抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin H
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
周期素H抗体产品介绍 background:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.
Function:
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
周期素H抗体
hz-3936R SLC27A2/ACSVL1 长链脂肪酸辅酶A连接酶抗体
hz-2034R CRIM1 富含半胱氨酸运动神经元蛋白1抗体
hz-2743R Slit2/Slil3 神经迁移蛋白Slit2/3抗体
hz-0994R SLT/SLT-IIe/O139 猪水肿素(O139)菌体蛋白抗体
hz-1895R SLC39A6 SLC39A6抗体
hz-1382R SNAI2/SLUG 锌指转录因子Slug抗体
hz-5635R phospho-SNAI2(Ser155+Ser158+Ser160+Tyr164+Tyr169) 磷酸化锌指转录因子Slug抗体
hz-3579R SLC40A1 细胞膜铁转运蛋白FP1抗体
hz-3667R SLC44A1/CD92 溶质转运蛋白家族44成员1抗体
hz-1619R Smad1 细胞信号转导分子Smad-1抗体
hz-3417R Phospho-Smad1(Ser206) 磷酸化细胞信号转导分子Smad-1抗体
hz-3418R Phospho-Smad1/5(Ser463/465) 磷酸化细胞信号转导分子Smad-1/5抗体
hz-0718R Smad2 细胞信号转导分子Smad-2抗体
hz-2224R phospho-Smad2(Ser465) 磷酸化Smad2抗体
hz-0585R Smad4 Smad4抗体
hz-2973R SMAD5 细胞信号转导分子SMAD5抗体
hz-0566R Smad7/Smad6 Smad 7抗体
hz-0457R phosphor-SMAD2(Ser425) 磷酸化细胞信号转导分子SMAD2抗体
hz-3419R Phospho-Smad2(Ser465/467) 磷酸化细胞信号转导分子SMAD2抗体
hz-3420R Phospho-Smad2(Ser245/250/255) 磷酸化细胞信号转导分子SMAD2抗体
hz-5618R Phospho-Smad2(Thr220) 磷酸化细胞信号转导分子SMAD2抗体
hz-3484R Smad3 细胞信号转导分子SMAD3抗体
hz-3425R Phospho-Smad3(Ser423/425) 磷酸化细胞信号转导分子SMAD3抗体
hz-5616R Phospho-Smad3(Ser425) 磷酸化细胞信号转导分子SMAD3抗体
hz-5617R Phospho-Smad3(Ser208) 磷酸化细胞信号转导分子SMAD3抗体
hz-3568R SMC1 染色体结构维持蛋白1抗体
hz-3406R Phospho-SMC1 (Ser360) 磷酸化染色体结构维持蛋白质１抗体
hz-3407R Phospho-SMC1(Ser957) 磷酸化染色体结构维持蛋白质１抗体
hz-5735R SMC3/CSPG6 基底膜相关软骨素蛋白多糖抗体
hz-4253R SMAD9 SMAD家族9抗体
hz-0259R SM-MHC 心肌肌球蛋白抗体（α-myosin）
