获取电话英文名称 CREB-1
中文名称 环腺苷酸应答元件结合蛋白抗体
别 名 Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB 1; CREB1; MGC9284; Transactivator protein;CREB.
说 明 书 0.1ml 0.2ml
研究领域 信号转导
抗体来源 Mouse
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 环腺苷酸应答元件结合蛋白抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CREB-1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
环腺苷酸应答元件结合蛋白抗体产品介绍 background:
Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory. CREB knock out mice show diminished learning ability.
Function:
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
环腺苷酸应答元件结合蛋白抗体
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hz-1392R CDC34/UBC3 细胞周期调控因子34
hz-4295R CDC40 细胞分裂周期同源蛋白40抗体
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hz-5113R CDCA4 细胞分裂周期相关蛋白4抗体
hz-3555R CDC42 细胞分化周期CDC42蛋白抗体
hz-3369R Phospho-CDC42 (Ser71) 磷酸化细胞分化周期CDC42蛋白抗体
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hz-3483R Phospho-CDK2 (Thr160) 磷酸化周期素依赖性激酶2抗体
hz-5277R Phospho-CDK2 (Thr14) 磷酸化周期素依赖性激酶2抗体
hz-1680R CDK3 周期素依赖性激酶3抗体
hz-0633R CDK4 周期素依赖性激酶4抗体
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hz-5727R HEC1 癌细胞高表达蛋白Hec1抗体
hz-0559R CDK5 周期素依赖性激酶5抗体
hz-5728R HURP/DAP5 肝癌上调蛋白抗体
hz-0568R CDK6 周期素依赖性激酶6抗体
hz-5286R phospho-CDK6 (Tyr13) 磷酸化周期素依赖性激酶6抗体
hz-5287R phospho-CDK6 (Tyr24) 磷酸化周期素依赖性激酶6抗体
hz-0569R CDK7 周期素依赖性激酶7抗体
hz-5729R LGALS3BP 可溶性半乳糖凝集素3结合蛋白抗体
