获取电话英文名称 CDK4
中文名称 周期素依赖性激酶4抗体
别 名 Cdk 4; CDK4 protein; Cell division kinase 4; Cell division protein kinase 4; CMM 3; CMM3; Crk3; Cyclin dependent kinase 4; Melanoma cutaneous malignant 3; MGC14458; p34 cdk4; PSK J3; CDK4_HUMAN.
说 明 书 0.1ml 0.2ml 1ml
研究领域 肿瘤 细胞生物 染色质和核信号 信号转导 细胞周期蛋白 激酶和磷酸酶
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 周期素依赖性激酶4抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
细胞定位 细胞核 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDK4
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
周期素依赖性激酶4抗体产品介绍 background:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Function:
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
周期素依赖性激酶4抗体
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hz-0943R phospho-Androgen Receptor(Ser580) 磷酸化雄激素受体抗体
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hz-5191R phospho-Androgen Receptor (Ser212) 磷酸化雄激素受体抗体
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hz-2405R AKR1B1 醛糖还原酶抗体
hz-3751R ARA24 雄激素受体相关蛋白24抗体
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hz-0385R ARC/Arg3.1 ARC抗体
hz-1145R ARF6 ADP核糖基化因子6抗体
hz-1477R Arfaptin 1 ADP核糖基化因子结合蛋白1抗体
hz-4230R mSin3A 同源转录调节蛋白Sin3A抗体
hz-1442R Arfaptin 2 ADP核糖基化因子结合蛋白2抗体
hz-3006R phospho-arfaptin 2(Ser260) 磷酸化ADP核糖基化因子结合蛋白2抗体
hz-4202R Arhgef2/GEF H1 Rho鸟苷酸交换因子2抗体
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hz-3953R COX1/MTCO1 细胞色素c氧化酶1抗体
hz-2562R COX7A2 细胞色素c氧化酶7A2抗体
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hz-3935R COX6B 细胞色素C氧化酶亚基6B抗体
hz-3763R Activin A Receptor Type IB 激活素受体1B抗体
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