获取电话英文名称 Exportin-2
中文名称 细胞凋亡敏感性基因抗体
别 名 Cellular Apoptosis Susceptibility; exportin-2; CAS; Cellular apoptosis susceptibility protein; Chromosome segregation 1 (yeast homolog) like; Chromosome segregation 1 Like; Chromosome segregation 1 like protein; Chromosome segregation gene CSE1; CSE 1; CSE 1 chromosome segregation 1 like; CSE 1 chromosome segregation 1 like protein; CSE 1L; CSE1; CSE1 chromosome segregation 1 like; CSE1 chromosome segregation 1 like protein; CSE1L; Exp 2; Exp2; Exportin 2; Exportin2; Exportin-2; Importin alpha re exporter; XPO2_HUMAN; Chromosome segregation 1-like protein; Importin-alphare-exporter.
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 细胞凋亡敏感性基因抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 107kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CAS
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
细胞凋亡敏感性基因抗体产品介绍 background:
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
Function:
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
细胞凋亡敏感性基因抗体
hz-8260R DHPS1 短链脱氢还原酶1抗体
hz-8261R DHRS13 短链脱氢还原酶13抗体
hz-8262R DHRS7 视网膜短链脱氢酶/还原酶家族7抗体
hz-8263R DHRSX 短链脱氢酶/还原酶家族X抗体
hz-8264R DHRS4 短链脱氢酶/还原酶家族4抗体
hz-8265R DHRS7C 短链脱氢酶/还原酶家族7C抗体
hz-8266R DHRS4L2 短链脱氢酶/还原酶家族4样2蛋白抗体
hz-8267R GIMAP1 GTP酶IMAP家族成员1抗体
hz-8268R GIMAP2 GTP酶IMAP家族成员2抗体
hz-8269R GIMAP3 GTP酶IMAP家族成员3抗体
hz-8270R GIMAP4 GTP酶IMAP家族成员4抗体
hz-8271R GIMAP5 GTP酶IMAP家族成员5抗体
hz-8272R GIMAP6 GTP酶IMAP家族成员6抗体
hz-8273R GIMAP7 GTP酶IMAP家族成员7抗体
hz-8274R GIMAP8 GTP酶IMAP家族成员8抗体
hz-8275R GPRIN1 G蛋白调节诱导神经突增生蛋白1抗体
hz-8276R GPRIN2 G蛋白调节诱导神经突增生蛋白2抗体
hz-8277R GPRIN3 G蛋白调节诱导神经突增生蛋白3抗体
hz-8278R DIRC2 干扰肾细胞癌蛋白2抗体
hz-8279R p400 p400蛋白抗体
hz-8280R DNAJC7 DNAJC7蛋白抗体
hz-4167R VAV1 鸟苷酸转换因子VAV1抗体
hz-8281R DNMBP 动力结合蛋白DNMBP抗体
hz-8282R DPH2 白喉酰胺生物合成样蛋白2抗体
hz-8283R CRMP5 二氢嘧啶酶相关蛋白5抗体
hz-8284R Phospho-CRMP2 (Thr514+Ser518) 磷酸化二氢嘧啶酶样2抗体
hz-8285R CRMP4/DRP3 脑衰蛋白反应调节蛋白4抗体
hz-5593R phospho-VAV1(Tyr160) 磷酸化鸟苷酸转换因子VAV1抗体
hz-5594R phospho-VAV1(Tyr174) 磷酸化鸟苷酸转换因子VAV1抗体
hz-8286R DYDC1 DYDC1蛋白抗体
hz-8287R DHP/Dihydropyrimidinase 二氢嘧啶抗体
