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德国耶拿 multi N/C 3100 TOC总有机碳/总氮分析仪型号： multi N/C 3100 -
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珀金埃尔默PerkinElmer NexION 1100/1000G ICP-MS型号： NexION 1100/1000G ICP-MS -
高分辨热场发射扫描电镜 SU3900/SU3800 SE Series型号： SU3900/SU3800 SE Series
获取电话英文名称 BLM
中文名称 Bloom综合征相关蛋白抗体
别 名 Blooms Syndrome Protein Blm; BLM; BLM_HUMAN; Bloom Syndrome; Bloom syndrome protein; Bloom syndrome RecQ helicase like; BS; DNA Helicase; DNA helicase RecQ like type 2; MGC126616; MGC131618; MGC131620; RECQ 2; RECQ like; RecQ like type 2; RecQ protein like 3; RecQ Protein-like 3; RECQ-2; RECQ-Like; RecQ-like type 2; RECQ2; RECQL 2; RECQL 3; RECQL-2; RECQL-3; RECQL2; RECQL3; type 2.
说 明 书 0.2ml
研究领域 细胞生物 发育生物学 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500Bloom综合征相关蛋白抗体 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 159kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human BLM/Blooms Syndrome Protein Blm
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Bloom综合征相关蛋白抗体产品介绍 background:
Bloom’s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom’s syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom’s syndrome patients. One characteristic of Bloom’s syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom’s cells.
Function:
Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
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hz-3920R ADCY2 腺苷酸环化酶2抗体
hz-4021R ADCY3 腺苷酸环化酶3抗体
hz-3921R ADCY4 腺苷酸环化酶4抗体
hz-3922R ADCY5 腺苷酸环化酶5抗体
hz-3923R ADCY6 腺苷酸环化酶6抗体
hz-3924R ADCY7 腺苷酸环化酶7抗体
hz-3925R ADCY8 腺苷酸环化酶8抗体
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hz-1962R ACD 肾上腺皮质发育异常蛋白抗体
