骨形态发生蛋白1/胶原C蛋白肽链内切酶抗体

英文名称    BMP1    

中文名称    骨形态发生蛋白1/胶原C蛋白肽链内切酶抗体    

别    名    BMP 1; BMP-1; Bone morphogenetic protein 1; Mammalian tolloid protein; mTld; PCOLC; PCP; ProCollagen C endopeptidase; Procollagen C proteinase; TLD; BMP1_HUMAN.    

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  信号转导  细胞骨架  细胞外基质      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 骨形态发生蛋白1/胶原C蛋白肽链内切酶抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    98kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human BMP1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

骨形态发生蛋白1/胶原C蛋白肽链内切酶抗体产品介绍    background:

Bone morphogenetic protein 1 (BMP1) was first identified in osteogenic extracts of bone. It is an extracellular zinc endopeptidase, implicated in morphogenetic processes in a broad range of species. BMP1 is a member of the astacin family of metalloproteinases. The astacin family includes BMP1, astacin, meprin A and B, tolloid-like proteins, and choriolysin. BMP1 is involved in extracellular matrix (ECM) formation, suggesting that a functional link may exist between astacin metalloproteinases, growth factors, and cell differentiation and pattern formation during development. The name PCP reflects this enzyme’s involvement in the collagen deposition of growing bone. The enzymes known as the procollagen C and N proteinases (PCP and PNP) are involved in the processing of fibrillar procollagen precursors to mature collagens, which is an essential requirement for fibril formation. PCP cleaves the C-terminus from procollagen, to allow the formation of mature, triplehelical collagen. The N-terminus is cleaved by the procollagen N-proteinase (PNP or ADAM-TS2). Defects in PNP have been linked to the skin disorder dermatosparaxis, and defects in BMP1 are thought to lead to aberrant collagen processing, and connective tissue disorders. Many forms of BMP1 have been reported, with varying truncation at the C-terminus. The long form of BMP1 is most similar to the tolloid-like proteins, which have extra EGF-like and CUB domains.

Function:
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD).    

骨形态发生蛋白1/胶原C蛋白肽链内切酶抗体公司更多热销抗体产品如下：

hz-0533P GABAB1(GABAb Receptor 1)  g-氨基丁酸B1受体(多肽)

hz-1293P GABABR2/GB2(GABA B Receptor 2)  γ1氨基丁酸A型受体B2抗原

hz-1302P GAD-67 (glutamate decarboxylase 67)  谷氨酸脱羧酶-67抗原

hz-1361P GADD153(Growth arrest and DNA damage-inducible 153)  生长抑制DNA损伤基因153抗原

hz-1641P phospho GAP-43(pSer41)(phospho Growth associated protein 43 )  磷酸化神经生长相关蛋白43抗原

hz-0834P GAPDH  3-磷酸甘油醛脱氢酶(人)抗原

hz-2209P CXCR3/CD183 peptide  细胞表面趋化因子受体3抗原

hz-1452P GATA-3(GATA binding factor 3)  GATA结合蛋白3抗原

hz-1778P GATA-4(GATA binding factor 4)  GATA结合蛋白4抗原

hz-1250P Gax(growth arrest-specific homeobox)  生长终止特异性同源盒基因抗原

hz-1288P GDF8/MSTN(growth differntiation factor 8)  生长分化因子8抗原

hz-1024P GDNF (Glial cell line-derived neurotrphic factor)  胶质细胞源性神经营养因子抗原

hz-1160P Gelsolin  凝溶胶蛋白抗原

hz-0844P GFP  绿色荧光蛋白

hz-0890P GFP  绿色荧光蛋白

hz-1173P GITR (glucocorticoidinduced tumor necrosis factor receptor)  糖皮质激素诱导肿瘤坏死因子受体抗原

hz-1206P GLI1(GLI-Kruppel family mhzber 1)  下游转录因子Gli1蛋白抗原

hz-0933P GLP-1/KG-31(Glucagon-like peptide-1) peptide  胰高血糖素样肽-1（多肽）

hz-0085P GLP-1 peptide  胰高血糖素样肽-1（多肽）

hz-1559P GLP-1R peptide  胰高血糖素样肽-1受体多肽

hz-1207P GLUT3(Glucose transporter 3)  葡萄糖转运蛋白3抗原

hz-0999P GM-CSF(Granulocyte-Macrophage Colony Stimulating Factors)  粒细胞-巨噬细胞克隆刺激因子抗原

hz-1226P GPA33(glycoprotein A33 transmhzbrane)  糖蛋白A33(跨膜)抗原

hz-2426P glypican 1  磷脂酰基醇蛋白聚糖-1抗原

hz-1112P GPC3(glypican 3; Intestinal protein OCI-5; GTR2-2; MXR7)  磷脂酰基醇蛋白聚糖-3(多肽)

hz-2159P Glypican 4(Glypican proteoglycan 4)  磷脂酰基醇蛋白聚糖-4抗原

hz-1465P GRB2/ASH peptide  生长因子受体结合蛋白2抗原

hz-1351P GZMB/CCPI(Granzyme B)  颗粒酶B抗原