获取电话英文名称 BubR1
中文名称 有丝分裂检验点蛋白BubR1抗体
别 名 Beta homolg of S. cerevisiae BUB 1; Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles; BUB 1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta; Bub1A; BUB1B; BUB1B_HUMAN; BUB1beta; BUBR1; Budding Uninhibited by Benzimidazoles 1 beta; hBUBR1; MAD3/BUB1 related protein kinase; MAD3/BUB1-related protein kinase; MAD3L; Mitotic checkpoint gene BUB1B; Mitotic checkpoint kinase MAD3L; Mitotic checkpoint serine/threonine protein kinase BUB1 beta; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; Protein SSK1; SSK 1; SSK1.
说 明 书 0.2ml
研究领域 肿瘤 细胞生物 免疫学 染色质和核信号 细胞周期蛋白 激酶和磷酸酶
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Cow, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 有丝分裂检验点蛋白BubR1抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 120kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human BubR1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
有丝分裂检验点蛋白BubR1抗体产品介绍 background:
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]
Function:
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
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hz-0326G Goat Anti-Bovine IgG 羊抗牛IgG
hz-0296G Goat Anti-Mouse IgG 羊抗小鼠IgG
hz-0368G Goat Anti-Mouse IgM 羊抗小鼠IgM
hz-0293G Goat Anti-rat IgG 羊抗大鼠IgG
hz-0358G Goat Anti-Guinea pig IgG 羊抗豚鼠IgG
hz-0295G Goat Anti-rabbit IgG 羊抗兔IgG
hz-0310G Goat Anti-Chicken IgG 羊抗鸡IgG
hz-0297G Goat Anti-human IgG 羊抗人IgG
hz-0345G Goat Anti-human IgM 羊抗人IgM
hz-0297M Mouse Anti-human IgG 小鼠抗人IgG
hz-0345M Mouse Anti-human IgM 小鼠抗人IgM
hz-0294M Mouse Anti-Goat IgG 小鼠抗羊IgG
hz-0295M Mouse Anti-rabbit IgG 小鼠抗兔IgG
hz-0369M Mouse Anti-Rabbit IgM 小鼠抗兔IgM
hz-0293M Mouse Anti-rat IgG 小鼠抗大鼠IgG
