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仪器信息网试剂标物化学试剂有机试剂洛莫司汀

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上海沪震实业有限公司

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洛莫司汀

洛莫司汀

价格：￥ 1

品牌：AMRESCO

供货周期：现货

货号：hz123247

规格：g/mg

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详细信息

详细信息

洛莫司汀

98%

Product Name: Lomustine

别名:	1-(2-氯乙基)-3-环己基-1-亚硝基脲
CAS号:	13010-47-4
分子式:	C₉H₁₆ClN₃O₂
分子量:	233.70
EINECS编号:	235-859-2
MDL号:	MFCD00012392

洛莫司汀

用途:	带有影响细胞DNA的抗肿瘤药物。洛莫司汀诱导A2870细胞p53的表达
熔点:	89.0 -93.0 °C
贮存:	-20°C
生化和生理学机理:	Description: IC50 Value: N/A Lomustine (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy. in vitro: vincristine and lomustine trigger apoptosis in all these cells through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively [1]. There was significant correlation between the level of cadherin-associated protein beta 1 (CTNNB1) and Aurora kinase A (STK15) proteins and neurotrophic tyrosine kinase receptor type 3 (TRKC) mRNA and the proportion of apoptosis induced by vincristine, the combination of both drugs, and lomustine, respectively [4]. in vivo: IC50 values for CCNU admixed and encapsulated with lipid vesicles were 18+/-4.9 and 14.0+/-2.2 microM, respectively, compared to 83+/-11.0 microM for free CCNU in rats [2]. Eight of the 19 dogs (42%) had a measurable response to CCNU. One dog had a durable complete response for 440 days. Seven dogs (37%) had a partial response for a median and mean duration of 77 days and 109 days, respectively (range, 21-254 days) [3]. Clinical trial: N/A

洛莫司汀

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