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Product Name: Paclitaxel
| 别名: | 紫杉醇 |
| CAS号: | 33069-62-4 |
| 分子式: | C47H51NO14 |
| 分子量: | 853.91 |
| MDL号: | MFCD00869953 |
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| 用途: | 有效的抗肿瘤的药物;结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕获在细胞周期的G2 / M期。 |
| 熔点: | 213-216℃ |
| 特定比重: | 1.39 |
| 比旋光度: | -49 ° (C=1, MeOH) |
| 贮存: | 储存温度2-8°C |
| 生化和生理学机理: | Paclitaxel is a compound extracted from the Pacific yew tree with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). Paclitaxel inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Paclitaxel induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors. |
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