Product Name: Celastrol
别名: | 雷公藤红素 ;南蛇藤素 |
CAS号: | 34157-83-0 |
分子式: | C29H38O4 |
分子量: | 450.61 |
MDL号: | MFCD03424073 |
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介绍: | 不溶于水。 |
用途: | 雷公藤红素是一种强力抗氧化,抗发炎剂。它是一种新型的HSP90的抑制剂(扰乱Hsp90/Cdc37复合物),抗癌(抗血管生成 - 抑制VEGFR的表达);抗氧化剂(抑制脂质过氧化反应)和抗发炎活性(抑制iNOS及炎性细胞因子的生产)。 |
特定比重: | 1.2 |
贮存: | 储存温度 -20°C |
生化和生理学机理: | Celastrol (Tripterin) is a plant-derived triterpene. Celastrol(Tripterin) has anti-inflammatory and immunosuppressive activity. Celastrol(Tripterin) is Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NFκB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 μM). |