找不到产品?留下需求帮您找
一键询价Product Name: Cholecalciferol (D3)
别名: | 维生素D3 ;胆骨化醇,活化7-去氢胆固醇,9,10-开环胆甾-5,7,10(19)-三烯-3beta-醇 |
CAS号: | 67-97-0 |
分子式: | C27H44O |
分子量: | 384.64 |
EINECS编号: | 200-673-2 |
MDL号: | MFCD00078131 |
![]() |
介绍: | 脂溶性维生素,不溶于水,水溶性: <0.1 g/L (20°C) 溶于醇、醚、丙酮和氯仿等大多数有机溶剂,微溶于植物油。在潮湿空气中几天就氧化失活,纯结晶在棕色真空安瓿中冰箱相存放一年后仅有极微量变质。 |
用途: | Vitamin D3 通过受体起作用,该受体是具配体依赖性转录因子大家庭的一员,调控正常细胞和癌细胞的增殖和分化,对乳腺癌、结肠癌和前列腺癌具抗增殖、抗转移效果。肠和骨骼内激活的Vitamin D受体还能维持钙吸收和内平衡。 |
熔点: | 84-85℃ |
特定比重: | 0.96 |
比旋光度: | 108 ° (C=0.5, EtOH) |
贮存: | 2-8°C 避光保存 |
敏感性: | 对光敏感 |
生化和生理学机理: | Cholecalciferol is a naturally occuring form of vitamin D. Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis. |