获取电话石杉碱甲
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Product Name: (-)-Huperzine A
| 别名: | (-)-石杉碱甲 |
| CAS号: | 102518-79-6 |
| 分子式: | C15H18N2O |
| 分子量: | 242.32 |
| MDL号: | MFCD01714949 |
石杉碱甲
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| 用途: | 石杉碱甲不仅通过抑制胆碱酯酶活性，还可以通过影响自由基系统，降低生长抑素、细胞内[Ca2+]、谷氨酸含量，提高钙调蛋白(CaM)和钙调蛋白的信使核糖核酸(CaM mRNA)表达水平等多种药理机制，提高认知功能和学习记忆能力。 |
| 特定比重: | 1.2 |
| 贮存: | 贮存温度-20℃ |
| 可溶性: | 易溶于氯仿，溶于甲醇、乙醇，微溶于水 |
| 生化和生理学机理: | Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease. |
石杉碱甲
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