仪器信息网试剂标物生化试剂常用生化试剂藤黄酸

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藤黄酸

价格：￥ 1

品牌：AMRESCO

供货周期：现货

货号：hz101480

型号：g/mg

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详细信息

≥97% (HPLC)

Product Name: Gambogic acid

介绍:	不溶于水
用途:	藤黄酸作为蛋白酶激活和凋亡诱导剂，会捕获细胞周期的G2 / M期，而且造成不可逆。
熔点:	81.8℃
沸点:	280℃
特定比重:	1.29
贮存:	储存温度-20°C
生化和生理学机理:	Description: IC50 Value: 1.21 uM (Bcl-2); 1.47 uM (Bcl-xl) Gambogic acid is a xanthonoid that is derived from the brownish or orange resin from Garcinia hanburyi. This natural chemical has shown promising antitumor activity in clinical trials with mice. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, respectively. in vitro: GA significantly inhibited the growth of JeKo-1 cells in a dose- and time-dependent manner. The maximum GA-induced cytotoxity was evident at 36 hrs exposure to 4 μg/mL GA. The IC50 of 12, 24 and 36 hrs of GA treatment for JeKo-1 cells was 0.73, 0.72 and 0.55 μg/mL respectively. GA induces apoptosis in JeKo-1 cells but not in normal bone marrow cells, which was involved in reducing the membrane potential of mitochondria, activating caspases-3, -8 and -9 and d

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