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氨基核苷嘌呤霉素

氨基核苷嘌呤霉素

价格： ￥ 1

品牌：AMRESCO

供货周期： 现货

货号：hz102404

规格：96t/48t

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氨基核苷嘌呤霉素

98%

Product Name: Puromycin aminonucleoside

别名:氨基核苷嘌呤霉素
CAS号:58-60-6
分子式:C12H18N6O3
分子量:294.31
EINECS编号:200-388-3
MDL号:MFCD00063462

氨基核苷嘌呤霉素


特定比重:1.7
贮存:储存温度2-8°C
生化和生理学机理:

Description:
IC50 Value: N/A
 Puromycin Aminonucleoside (3'-Amino-3'-deoxy-N6,N6-dimethyladenosine) is the aminonucleoside portion of the antibiotic puromycin. It is a puromycin analog which does not inhibit protein synthesis or induce apoptosis. Used in the study of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats.
in vitro: PA-induced apoptosis was associated with increased p53 expression, which was completely blocked by dexamethasone. Furthermore, the inhibition of p53 by the p53 inhibitor pifithrin-alpha protected against PA-induced apoptosis. Dexamethasone also lowered the increase in the proapoptotic Bax, which was increased by PA, and increased expression of the antiapoptotic Bcl-xL protein [1]. Expression of PMAT in Madin-Darby canine kidney cells significantly increased cell sensitivity to PAN [2].
in vivo: The number of podocytes per glomerulus was 95.5±17.6 in the control rats, 90.7±19.2 on Day 4 and 90.7±26.2 on Day 7 in PAN nephrosis rats. The amount of nephrin per glomerulus in control rats was 1.02±0.11 fmol and those in PAN nephrosis rats were reduced to 0.46±0.06 fmol and 0.35±0.04 fmol on Day 4 and Day 7 [3].
Toxicity: The 24-h urinary protein excretion of treated rats compared with controls (PAN rats) 9 days after PAN injection was 16 +/- 2 mg and 524 +/- 55 mg, respectively (p < .01). Morphological examination also demonstrated that the glomerular epithelial cells were protected against PAN-induced damage [4].
Clinical trial: N/A
 

氨基核苷嘌呤霉素





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