ACPA (Anti-Citrullinated Protein Antibodies) ELISAACPA (Anti-Citrullinated Protein Antibodies) ELISA|Demeditec DE7170
价格： ￥ 4664
品牌：
供货周期： 现货
货号：DE7170
型号：96 Tests
获取电话产 地：Demeditec
产品货号：DE7170
产品规格：96 Tests
产品说明：
Special remarks:
NAME AND INTENDED USE
ACPA is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of IgG class autoantibodies against citrullinated Proteins (ACP), in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of rheumatoid arthritis.
SUMMARY AND EXPLANATION OF THE TEST
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. The main characteristics of RA is joint inflammation that results in joint damage and loss of function. An early diagnosis of RA and an immediate beginning of an appropriate treatment is important to prevent a complete joint damage.
RA is diagnosed primarily on clinical manifestations and serological suppport has, up to now, been mainly restricted to the determination of autoantibodies against rheumatoid factor (RF). RF is a sensitive serological marker for RA with a moderate specificity of about 70%. In several studies it has been demonstrated that the determination of antibodies against citrullinated arginine residues in filament proteins occurs in RF negative patients. Citrullination is an peptidylarginine deiminase (PAD) catalysed process in which the amino acid arginine (Arg) is modified to citrullin. During this conversion, the positively charged NH2-group is hydrolyzed to an oxygen group.
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