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仪器信息网试剂标物生化试剂常用生化试剂 Bisindolylmaleimide I

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Bisindolylmaleimide I

价格：面议

品牌：GenDepot

供货周期：现货

货号：BC006-005

规格：5mg

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详细信息
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详细信息

M.Wt: 412.48

Formula: C₂₅H₂₄N₄O₂

Solubility: Soluble in DMSO

Purity: >99 %

CAS No: [133052-90-1]

Cat No	Size	Price($)

BC006-005	5mg	134

BC006-010	10mg	254

BC006-025	25mg	536

Biological Activity:

Bisindolylmaleimide I (BIM) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine. It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKC慣-, 棺1-, 棺2-, 款-, 灌-, and 琯-isozymes.1 BIM directly inhibits GSK3 in primary adipocyte lysates (IC₅₀ = 360 nM) and in GSK3棺 immunoprecipitates derived from rat epididymal adipocytes (IC₅₀ = 170 nM). This compound also competitively antagonizes the 5-HT3 receptor with a Ki value of 61 nMbr>

Synonym

Gö 6850

GF 109203X

BIM

Store at -20^oC , Desiccate

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