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Apolipoprotein CIII(APOC3)antibody
Cat.#: 3125-1
Rabbit Monoclonal Antibody
Clone ID: EPR1371(2)
Swiss Prot: P02656
Mol Weight: 11kDa
Size: 100ul
Description
Apolipoprotein CIII (Apo CIII) is one of 9 known polymorphic forms of apolipoproteins. The apolipoproteins function as stabilizers of intact lipoprotein particles. Specifically, Apo CIII is a very low density lipoprotein (VLDL) protein (1). Apo CIII is involved in inhibition of lipoprotein and hepatic lipases. It is thought to delay catabolism of triglyceride-rich particles. A defect in Apo CIII has been linked to hyperalphalipoproteinemia (HLAP), which causes increased levels of high density lipoprotein (HDL) (2).
Recommended Applications
WB, IHC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:250 - 500
Species Reactivity
Human
Mouse cross reactivity tested by western blot and IHC
Rat cross reactivity tested by western blot only
Products Data
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Western blot analysis on (A) human plasma and (B) HDL cell lysates using anti-Apolipoprotein CIII RabMAb (cat. # 3125-1).
Immunohistochemical staining of paraffin-embedded human liver tissue using anti-Apolipoprotein CIII RabMAb (cat. #3125-1).
Specificity
A synthetic peptide corresponding to residues in human Apolipoprotein CIII was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
APOC3 antibody, APOCIII antibody, MGC150353 antibody, Apolipoprotein C-III antibody, Apolipoprotein C3 antibody
Description References
1. Hirano, T, et al; Kidney International 63:2171–2177, 2003. 2. Hirano, K, et al; Arteriosclerosis, Thrombosis, and Vascular Biology, 15:1849-1856, 1995.