获取电话
Abi-2(ABI2)antibody
Cat.#: 3189-1
Rabbit Monoclonal Antibody
Clone ID: EPR3906
Swiss Prot: Q9NYB9
Mol Weight: 75kDa
Size: 100ul
Description
Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for Rac-dependent cytoskeletal reorganization in response to growth factor stimulation (1). Abi-2 may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases Abi-1 and/or Abi-2. This protein may be involved in cytoskeletal reorganization, and it regulates Abi-1/c-Abl-mediated phosphorylation of MENA (2).
Recommended Applications
WB, IHC, ICC, IP
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:250 - 500
ICC: 1:500 - 1,000
IP: 1:10 - 100
Species Reactivity
Human, Mouse, Rat
Mouse cross reactivity tested by western blot and IHC
Rat cross reactivity tested by western blot only
Products Data
 |
 |
 |
Western blot analysis on (A) HeLa, (B) Jurkat, (C) K562, (D) SH-SY5Y, and (E) HepG2 cell lysates using anti-Abi-2 RabMAb (cat. #3189-1).
Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-Abi-2 RabMAb (cat. #3189-1).
Immunofluorescent staining of HeLa cells using anti-Abi-2 RabMAb (cat. #3189-1).
Specificity
A synthetic peptide corresponding to residues in human Abi-2 was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
ABI2 antibody, ABI-2 antibody, ABI2B antibody, AIP-1 antibody, AblBP3 antibody, SSH3BP2 antibody, argBPIA antibody, argBPIB antibody, Abl interactor 2 antibody, Arg-binding protein 1 antibody
Description References
1. Courtney KD, et al. Mol Cell Neurosci 16(3):244-57, 2000
2. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2010)