CPSA日程公布论文投稿截止3月15日

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分享： 2011/03/09 11:16:51

　　2011年4月13-16日，化学与药物结构分析领域内享有极高声誉的国际性会议——CPSA将再次于中国上海召开。一年一度的CPSA起始于1998年，已经连续举办了十三届，本界会议的主题是“改变药物研发模式：东西方的交遇。”

　　“CPSA上海2011”是一个为科学家们提供共同、平等交流的场所和平台，所有报告内容都将是报告人的切身经历和经验，内容涉及多个方面，包括：政策法规、ADME和生物分析、药物相互作用和药物遗传学、药物研发中的PK/PD、药学/分析科学、外包策略探讨、新型给药技术、药物研发中的生物标记、生物制品发展、生物分析技术等。

　　会议同期活动还包括：短期培训、研讨班、专题讨论会、墙报、展览等。此次会议欢迎投递论文，2011年3月15日之前请把论文题目、作者、摘要发送到info@milestonedevelopment.com，字数控制在250字以内。另外，会议还设置了青年科学家奖，请于2011年3月15日前将申请表、摘要发送至wenfang.miao@pharmaron.com及ziqiang.z.cheng@gsk.com，主办方将为获奖者颁发现金奖励及获奖证书。

　　会议具体日程现公布如下：

　　Wednesday, April 13 - Workshops
　　Workshops
　　1:00 pm - 5:00 pm
　　Biotransformation: Lead Optimization and Clinical Candidate Selection
　　Through in Vitro ADME Evaluation
　　Workshop Leader: Mingshe Zhu, Bristol-Myers Squibb
　　Common in Vitro ADME Assays: Methods and Data Interpretation
　　Weiqing Chen, ChemPartner
　　Assessment of Transporter-Mediated Drug-Drug Interactions:
　　Current Strategy and Methodology
　　Cindy Xia, Millennium
　　Drug Metabolite Identification in Drug Discovery Using High-Resolution
　　Mass Spectrometry
　　Jie Xing, University of Shandong, China
　　Design Proper in Vitro ADME Studies to Meet Needs in Drug Discovery
　　Mingshe Zhu, Bristol-Myers Squibb
　　1:00 pm - 5:00 pm
　　Bioanalysis: LC-MS/MS Bioanalysis from Drug Discovery to Development:
　　Processes, Technologies and Regulations
　　Workshop Leader: Jian Wang, Bristol-Myers Squibb
　　Overview of LC-MS/MS Bioanalysis in Pharmaceutical Industry:
　　Processes and Applications
　　Danlin Wu, Roche
　　Technical Fundamentals in LC-MS/MS Bioanlytical Method Development,
　　Validation and Sample Analysis: Procedures, Issues and Solutions
　　Yuan-Qing Xia, Bristol-Myers Squibb
　　Performing Regulated Bioanalysis, Challenges and Case Studies from
　　a CRO Perspective
　　Xiaohang Shen, WuXi AppTec
　　Discovery Bioanalysis
　　Jian Wang, Bristol-Myers Squibb
　　1:00 pm - 5:00 pm
　　Pharmaceutical Analysis
　　Workshop Leaders: Gang Xue, Pfizer; Yong-Guo “Fred” Li, Roche
　　High Speed and High Efficiency Method Development
　　Gang Xue, Pfizer
　　ICH Q-Series, Key Points Exploration
　　Yong-Guo “Fred” Li, Roche
　　Dissolution Design and Testing, Critical for Oral Drug
　　Mufeng Xie, Shanghai Institute for Food and Drug Control (SIFDC))
　　Evening
　　Sponsor’s Dinner
　　Hosted by Thermo Fisher Scientific
　　Introduction and Welcome
　　Iain Mylchreest, Vice President and General Manager, Thermo Fisher Scientific
　　Applying Proven Proteomic Workflows and Tools for Quantitative Bioanalysis of
　　Large Molecules
　　Jonathan McNally, Marketing Manager for Bioanalysis, Thermo Fisher Scientific

　　Thursday, April 14 - Main Symposium
　　8:15 am – 8:30 am
　　Welcome
　　Mike Lee, Milestone Development Services
　　Ballroom 1-2
　　8:30 am - 8:45 am
　　Meeting Overview
　　Jing-Tao Wu, Millennium Pharmaceuticals
　　Ballroom 1-2
　　8:45 am – 9:30 am
　　Plenary Lecture
　　Challenges and Future Direction of Oncology Drug Development
　　Pete Smith, Senior Vice President, Millennium Pharmaceuticals
　　Ballroom 1-2
　　10:15 am - 11:45 am
　　Parallel Sessions
　　Parallel Track I ADME I
　　Ballroom 1
　　10:15 am - 11:45 am
　　Comparison of Regulatory Requirements on DMPK Package Chair: Jeff Zhang, Novartis
　　Overview of DMPK Package in China: Regulatory Requirement & Current Practice
　　Dafang Zhong, Shanghai Institute of Materia Medica
　　US/Europe Regulatory Requirements on Metabolites in Safety Testing
　　Mingshe Zhu, Bristol-Myers Squibb
　　US/Europe Regulatory Requirements on Drug/Drug Interactions
　　Mark Milton, Novartis
　　Parallel Track II Pharmaceutical Sciences
　　Rhine Ballroom
　　10:15 am - 11:45 am
　　Emerging Trends and Technologies in Pharmaceutical Sciences
　　Chair: Jack Chen, DSM
　　PAT Applications in a Quality-by-Design (QbD) Environment
　　Kevin Bittorf, Vertex Pharmaceuticals
　　Enhancing Product Performance Through Innovative Formulation and Manufacturing
　　Qun Lu, Merck
　　New Technology in Polymorph Studies
　　Beth Sarsfield, Bristol-Myers Squibb
　　Parallel Track III Bioanalytical
　　Ballroom 2
　　10:15 am - 11:45 am
　　Dried Blood Spots and Other Emerging Bioanalytical Technologies Chair: Naidong Weng, Johnson & Johnson
　　Applications of DBS for Clinical Bioanalysis Support
　　Tom Verhaeghe, Johnson & Johnson
　　Case Study of Dried Blood Spots Application in Toxicology Study
　　Luke Bi, Covance
　　High Resolution Accurate Mass Spectrometry in Quantitative Bioanalysis: Effect of
　　Mass Resolution and Extraction Window on Selectivity
　　Yuan-Qing Xia, Bristol-Myers Squibb
　　High-Throughput Bioanalysis Using an Ultra-fast On-line Extraction System
　　Wenying Jian, Johnson & Johnson
　　11:45 am - 1:15 pm Lunch & Roundtable Discussion
　　11:45 pm - 1:15 pm Sponsored Roundtable Workshops
　　Hosted by AB Sciex - Danube Ballroom
　　High Resolution Quantitation for Bioanalysis using AB Sciex 5600 Triple Tof
　　Hesham Ghobarah, AB Sciex
　　Targeted Peptide Quantitation using MIDAS Workflow
　　Wenhai Jin, AB Sciex
　　Hosted by McKinley Scientific - The Boardroom
　　Topic to be announced
　　1:15 pm – 5:00 pm
　　Parallel Sessions
　　Parallel Track I ADME II
　　Ballroom 1
　　1:15 pm - 2:45 pm
　　Drug-Drug Interactions
　　Chairs: Cindy Xia, Millennium; Angela Wong, Merck Serono
　　DDI of Herbal Medicines
　　Chuan Li, Shanghai Institute of Materia Medica
　　Transporter-mediated DDI
　　Cindy Xia, Millennium Pharmaceuticals
　　Pharmacogenetics in Drug Discovery and Development
　　Renke Dai, South China University of Technology
　　3:00 pm - 5:00 pm
　　ADME Optimization to Advance CNS and Oncology Drug Discovery & Development:
　　Industry Case Studies
　　Chairs: Zack Cheng, GlaxoSmithKline; Haojing Rong, Pfizer
　　Blood-Brain Barrier Transporters:
　　Friend or Enemy for CNS Drug Discovery and Development?
　　Zack Cheng, GlaxoSmithKline
　　Intranasal Administration for CNS Drug Delivery: Hope or Hype?
　　Haojing Rong, Pfizer
　　ADME Support of Oncology Programs:
　　Risk Management vs. Pursuit of Appropriate Drug-Like Properties
　　Hongjian Zhang, PharmaResources
　　Predictive Toxicology Approaches for Small Molecule Oncology Drugs
　　Vic Kadambi, Millennium Pharmaceuticals
　　Parallel Track II Pharmaceutical Analysis Summit
　　Ballroom 2
　　1:15 pm – 2:45 pm
　　High-speed, High-Resolution Techniques for Pharmaceutical Analysis
　　Chairs: Anne-Françoise Aubry, Bristol-Myers Squibb; Xiaoyi Gong, Merck
　　Chromatographic Methodology and Technology for Developing TCM
　　Xinmiao Liang, Dalian Institute of Chemical Physics
　　Mass Spectrometry and Ion Mobility-Based Techniques for Rapid Pharmaceutical
　　Analysis: No Sample Preparation?
　　Zhongli Zhang, Pfizer
　　Evaluation of Ionic Liquid Stationary Phases for GC-MS and GCxGC Analyses of
　　Fatty Acids in Marine Biota
　　Qun Gu, Dalian Institute of Chemical Physics
　　3:00 pm - 5:00 pm
　　Analytical Approaches for the Determination of Low-Level Impurities to Comply
　　with International Regulations
　　Chairs: Todd Gillespie, Eli Lilly and Company; Roman Szucs, Pfizer
　　Genotoxic Impurities in Drug Development
　　James An, Wilmington Pharmatech
　　Analytical Strategy for Quantifying Low-Level Genotoxic Impurities
　　Todd Gillespie, Eli Lilly and Company
　　Quantitation of API Impurities Near the Qualification Level
　　Tianmin Zhu, Hisun Pharmaceuticals
　　High-throughput Chiral Analyses
　　Xiaoyi Gong, Merck
　　Parallel Track III Workshop
　　Rhine Ballroom
　　1:15 pm - 5:00 pm
　　Absolute Quantification of Peptides and Proteins: From Sample Preparation and
　　Chromatography to ESI-MS/MS
　　Leaders: Gary Valaskovic, New Objective; Nalini Sadagopan, Agilent Technologies
　　5:00 pm - 6:00 pm
　　Poster Viewing - Yangtze Ballroom
　　6:00 pm - 9:00 pm
　　Dinner
　　Ballroom 1-2
　　Welcome Toast - Agilent Technologies
　　Keynote Lectures
　　Stable and Reactive Metabolites in Drug Research
　　Scott Obach, Pfizer
　　Simultaneous Determination of the PK profile of Clozapine and its Metabolites in
　　Rat Plasma Using a High-Resolution 6540 QTOF instrument
　　Lester C. Taylor, Shane Tichy, and Na Pi, Agilent Technologies

　　Friday, April 15
　　8:15 am – 9:00 am
　　Plenary Lecture
　　Ballroom 1-2
　　Multi-dimensional Chromatography-Mass Spectrometry for Protein Analysis
　　Xiangmin Zhang, Fudan University
　　9:30 am - 11:00 am
　　Parallel Sessions
　　Parallel Track I Novel Drug Delivery Technologies
　　9:30 am - 11:00 am
　　Chair: Mark Milton, Novartis
　　Ballroom 1
　　Antibody Drug Conjugates - A General Review
　　Mark Milton, Novartis
　　Drug Targeting and Nanotechnology
　　Yiqiao Hu, Nanjing University
　　Novel Technologies for the Delivery of Biologics
　　Zhixuan Wang, Novartis
　　Parallel Track II Biomarker Discovery
　　9:30 am - 11:00 am
　　Chairs: Scott Fountain, Pfizer; Nalini Sadagopan, Agilent
　　Ballroom 2
　　Application of Target and Mechanism Biomarkers in Advancing Biotherapeutics
　　and Pharmatherapeutics
　　Scott Fountain, Pfizer
　　Implementing Biomarkers into Clinical Trials on a Global Scale
　　Tom Turi and LiBin Ma, Covance
　　Proteomics Approaches to the Development of Plasma Markers for Predicting Pre-
　　Term Birth
　　Kevin P. Rosenblatt, The Brown Foundation Institute of Molecular Medicine
　　Parallel Track III Comparison of Regulations for Pharmaceutical Sciences
　　9:30 am - 11:00 am
　　Chair: Gang Xue, Pfizer
　　Rhine Ballroom
　　Reviews of CMC Requirements for Drug Development, Registration and Post
　　Approval
　　Yanyun Chen, Pfizer
　　CMC Requirements for Analytical/QC
　　Wenfang Miao, Pharmaron
　　11:00 am - 12:00 pm
　　Poster Session - Yangtze Ballroom
　　12:00 pm - 1:30 pm
　　Lunch / Roundtable Discussion
　　12:30 pm - 1:30 pm
　　Sponsored Roundtable Workshops
　　Hosted by Thermo Fisher Scientific - Danube Ballroo
　　Identification and Screening for Drug Impurities, Leachables, and Extractables
　　Using New Software and High Resolution Mass Spectrometery
　　Kate Comstock, Marketing Specialist for Drug Metabolism, Thermo Fisher Scientific
　　Hosted by New Objective - Boardroom
　　Topic to be announced
　　Gary Valaskovic, New Objective
　　1:30 pm – 5:00 pm
　　Parallel Sessions
　　Parallel Track I ADME III
　　Ballroom 1
　　1:30 am – 3:30 pm
　　Development of Biologics as Therapeutics Chair: Lawrence Gan, Biogen Idec; Haijing Rong, Pfizer
　　Introduction of Biologics
　　Jennifer Visich, Genentech
　　Biologics Drug Drug Interaction
　　Lewis Klunk, Biogen Idec
　　PK/PD of Biologics
　　Anup Zutshi, Pfizer
　　3:45 pm - 5:15 pm
　　PK/PD in Drug Discovery & Development Chairs: Jenny Zheng, Pfizer; Zhuohan Hu, Research Institute for Liver Diseases
　　The Myths of PK/PD - Empirical? Mechanistic? Or System?
　　Jenny Zheng, Pfizer
　　A Mechanistic-Based PK/PD Modeling for Drug Metabolism by CYP3A in Rat
　　Wei Lu, Peking University, China
　　Case History – Use of PK/PD in Drug Candidate Selections
　　Lawrence Gan, Biogen Idec
　　Application of PBPK and In-Vitro Hepatocyte Models to
　　Accurately Predict Human PK
　　Yurong Lai, Pfizer
　　Parallel Track II Regulated Bioanalysis Summit
　　Ballroom 2
　　1:30 pm - 3:30 pm
　　Regulated Bioanalysis: State of the Art Chair: Danlin Wu, Roche
　　Perspectives on Regional Differences in Bioanalytical Regulations
　　Mark Arnold, Bristol-Myers Squibb
　　Strategies to Avoid Pitfalls in Developing and Validating High-quality Quantitative
　　Bioanalytical Methods to Support Regulated Studies
　　Eric Yang, GlaxoSmithKline
　　Importance of Reagent Quality for Ligand Binding Assay Development
　　Roland Staak, Roche
　　Validation and Application of Ligand Binding Assays for Protein Therapeutics
　　Quantitation and Immunogenicity Testing: A GLP Bioanalytical Lab Perspective
　　Eginhard Schick, Roche
　　3:45 pm – 5:15 pm
　　Regulated Bioanalysis: Current Challenges
　　Chair: Anne Françoise-Aubry, Bristol-Myers Squibb
　　Unexpected Event Investigations in the Bioanalytical Laboratory
　　Anne Françoise-Aubry, Bristol-Myers Squibb
　　Bioanalytical Method Transfer: Challenges & Opportunities
　　Naidong Weng, Johnson & Johnson
　　Harmonization of Regulated Bioanalytical Operation at both U.S. and China Sites
　　XinPing Fang, XenoBiotic Laboratories
　　Parallel Track III Workshop
　　Rhine Ballroom
　　1:30 pm - 5:15 pm
　　Pharmacokinetic Applications in Drug Discovery and Development: Human PK and
　　Efficacious Dose Prediction
　　Workshop Leaders: Frances Wang, Astra Zeneca; Xingmei Han, Novartis
　　6:00 pm - 9:30 pm
　　CPSA Shanghai Gala Dinner
　　Ballroom 1-2
　　Held in conjunction with local bioanalytical and metabolism discussion groups
　　6:00 pm - 7:00 pm
　　Dinner Gala
　　7:00 pm - 7:30 pm
　　Awards and Announcements
　　7:30 pm - 9:30 pm
　　Point/Counterpoint Discussions
　　Future Direction of Pharmaceutical R&D in China
　　Moderator: Jeff Zhang, Novartis

　　Saturday, April 16
　　Morning
　　Joint session with local bioanalytical and metabolism discussion groups
　　Application of PK/PD in Drug Discovery and Development
　　Li Yu, Hoffmann-La Roche
　　Application of In-Vitro Data to Predict Clinical PK and Drug-Drug Interaction
　　by Simcyp
　　Jing Lin, Pfizer
　　Application of Radioisotopes in Drug Absorption, Distribution, Metabolism,
　　and Excretion Studies
　　Zhe-ming Gu, XBL-China