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磷酸化转录因子SOX9蛋白抗体
英文名称 phospho-SOX9 (Ser181)
中文名称 磷酸化转录因子SOX9蛋白抗体
别 名 SOX9 (phospho Ser181); SOX9 (phospho S181); p-SOX9 (phospho S181); SOX9(phospho S181); CMD 1; CMD1; CMPD 1; CMPD1; SOX 9; Sox9; SOX9_HUMAN; SRA 1; SRA1 antibody SRY (sex determining region Y) box 9 (campomelic dysplasia autosomal; SRY (sex determining region Y) box 9; SRY (sex determining region Y)-box 9; SRY (sex-determining region Y)-box 9 protein; Transcription factor SOX 9; Transcription factor SOX-9; transcription factor SOX9; campomelic dysplasia autosomal sex reversal.
产品类型 磷酸化抗体
研究领域 肿瘤 细胞生物 免疫学 发育生物学 信号转导 转录调节因子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human SOX9 around the phosphorylation site of Ser181:RK(p-S)VK
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
Sox9是软骨形成过程中一个十分关键的转录因子,虽然已经有研究表明骨形成蛋白2(bone morphogenetic protein 2,BMP2)能诱导Sox9的表达。
有学者认为;Sox9蛋白很可能与椎间盘退变有着密切的关系,Sox9是胶原蛋白合成过程中的一个重要的转录因子,且在软骨的发育、成熟过程中对胶原蛋白有着正向调控作用,Sox9蛋白在男性性腺调节睾丸发育中也有一定的作用。