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甲基化CpG结合蛋白2抗体
英文名称 MeCP2
中文名称 甲基化CpG结合蛋白2抗体
别 名 AUTSX 3; AUTSX3; Mbd 5; MECP-2; MeCP 2 protein; Methyl CpG binding protein 2 (Rett syndrome); Methyl CpG binding protein 2; MRX 16; MRX 79; MRX16; MRX79; MRXS 13; MRXS13; MRXSL; PPMX; RTS; RTT; WBP 10; WBP10. MECP2_HUMAN
研究领域 细胞生物 免疫学 发育生物学 染色质和核信号 神经生物学 转录调节因子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MeCP2:101-200/486
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3 and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
MECP2蛋白是一种丰富的染色质结合蛋白,属于DNA结合蛋白大家族中一员,是一种转录抑制因子,能选择性地与甲基化的CpG(甲基胞嘧啶)结合,特别是与含单个甲基化的CpG结合。MECP2的突变可以导致持续性神经系统退化(neurodegenerative disorder)Rett综合症。这个x-染色体相关综合症(X-linked syndrome)主要在女性身上体现, 他突变也可以导致男性的智力障碍,Rett综合征是一种严重影响儿童精神运动发育的神经遗传病。