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细胞衰老相关蛋白ASF1A抗体
英文名称 ASF1A
中文名称 细胞衰老相关蛋白ASF1A抗体
别 名 Anti silencing function 1A; ASF1 anti silencing function 1 homolog A; CCG1 interacting factor A; CG9383; CGI 98; CGI98 protein; CIA; dASF1; hAsf1; hAsf1a; hCIA; Histone chaperone ASF1A; HSPC146; ASF1A_HUMAN.
研究领域 肿瘤 细胞生物 免疫学 染色质和核信号 转录调节因子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow,
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/Test IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ASF1A:101-204/204
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 ASF1a belongs to the H3/H4 family of histone chaperone proteins. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication, repair and silencing.
ASF1a能够促进细胞衰老并且是与衰老有关的细胞周期停滞所必须的。HIRA/ASF1a介导的SAHF的形成过程直接促进细胞脱离细胞周期循环进入衰老阶段。研究人员还推测HIRA和ASF1a的改变可能使细胞无法脱离细胞周期并可能导致癌症的发生。