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鞘氨醇激酶1抗体
英文名称 SPHK1
中文名称 鞘氨醇激酶1抗体
别 名 sphingosine kinase 1; SK 1; SK1; SPHK 1; SPHK; SPK; SPK 1; SPK1; Sphk1; SPHK1_HUMAN.
研究领域 肿瘤 细胞生物 信号转导 细胞凋亡 激酶和磷酸酶 细胞分化
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit,
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42-52kDa
细胞定位 细胞核 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPHK1:1-100/384
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
SPHK1参与鞘氨醇代谢、G蛋白偶联受体蛋白信号转导途径,有抗细胞凋亡的作用,可被蛋白激酶C激活,参与细胞内信号转导级联、钙介导信号转导、调控细胞生长迁移、调控血管生成及成纤维细胞增殖。